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- W42513422 abstract "ABSTRACT A new type of perfusion reactor, based on a homogeneous reactor equipped with a microfiltration module on an external loop, yields significant increase in culture performances with OKT3 hybridoma: 1.5x107 cells/ml, 100 mg MAb/day.L and 2.5 g MAb/L of spent serum, compared to 2x106 cells/ml, 12 mg MAb/day.L and 0.9 g MAb/L of spent serum in a batch reactor. At 1 day–1, perfusion cultures can be maintained for more than two months with cell viability above 70 %. Both in batch and perfusion mode the specific rate of antibody production is found independent of the cell growth rate between 0.3 and 1.5 day–1. KEY WORDS: Perfusion reactor, hollow-fiber, microfiltration, kinetics, OKT3, high density" @default.
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- W42513422 date "1991-01-01" @default.
- W42513422 modified "2023-10-18" @default.
- W42513422 title "OPTIMIZATION OF OKT3 HYBRIDOMA CULTURES IN A PERFUSION STIRRED REACTOR" @default.
- W42513422 cites W1993592421 @default.
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- W42513422 doi "https://doi.org/10.1016/b978-0-7506-1103-9.50091-3" @default.
- W42513422 hasPublicationYear "1991" @default.
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