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- W4251345381 abstract "In their Commentary,1Spencer PS Palmer VS Lathyrism: aqueous leaching reduces grass-pea neurotoxicity.Lancet. 2003; 362: 1775-1776Summary Full Text Full Text PDF PubMed Scopus (7) Google Scholar Peter Spencer and Valerie Palmer miss the real point of Haileyesus Getahun and colleagues' Research letter,2Getahun H Lambein F Vanhoorne M Van der Stuyft P Food-aid cereals to reduce neurolathyrism related to grass-pea preparations during famine.Lancet. 2003; 362: 1808-1810Summary Full Text Full Text PDF PubMed Scopus (52) Google Scholar and instead give their own view on how neurolathyrism might be controlled. The point made by Getahun and colleagues is that supplementation of grass pea with food-aid cereals has significantly reduced the risk of neurolathyrism, and that such supplementation could be used as a continued approach to further reducing the risks. Instead of highlighting this aspect, Spencer and Palmer suggest steeping the dehusked pulse in hot water and boiling as a simple means of control. I would like to point out that this simple procedure will never be acceptable at a household level. Pulses in particular are favoured for their taste and flavour. No one will be willing to throw away the soup made from it and eat only the solid pulse. Detoxifying 50–100 g of the pulse on a laboratory bench is no doubt very effective, but householders will pass it off as a joke. Although different culinary methods of preparing a grass-pea meal based on regional and cultural backgrounds might have a role in the incidence of neurolathyrism, a point to remember is that for any boiled form of grass pea (porridge, soup, ghotu) most of the toxin will be in a solubilised form and thus available for absorption straight away. Absorption of toxins in bread or chapati made from the pulse will occur over a longer period. Our own findings3PratapRudra MP, Raghuveer Singh M, Junaid MA, Jyothi P, Rao SLN. Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism. Clin Biochem (in press).Google Scholar show that the neurotoxin in grass pea is indeed detoxified in human beings, in contrast to what happens in animals. Hence the form in which grass pea is presented to the system might well be an important point to consider in risk assessment. Although we keep debating how to reduce the risk of neurolathyrism, what Getahun and colleagues have reported is that in Ethiopia, a cereal food-aid supplementation has really worked and is indeed a very practical solution." @default.
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- W4251345381 date "2004-02-01" @default.
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- W4251345381 title "Prevention of neurolathyrism during drought" @default.
- W4251345381 doi "https://doi.org/10.1016/s0140-6736(04)15602-x" @default.
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