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• W4251440314 endingPage "739" @default.
• W4251440314 startingPage "729" @default.
• W4251440314 abstract "Abstract The major pathway of mRNA decay in yeast initiates with deadenylation, followed by mRNA decapping and 5′-3′ exonuclease digestion. An in silico approach was used to identify new proteins involved in the mRNA decay pathway. One such protein, Edc3p, was identified as a conserved protein of unknown function having extensive two-hybrid interactions with several proteins involved in mRNA decapping and 5′-3′ degradation including Dcp1p, Dcp2p, Dhh1p, Lsm1p, and the 5′-3′ exonuclease, Xrn1p. We show that Edc3p can stimulate mRNA decapping of both unstable and stable mRNAs in yeast when the decapping enzyme is compromised by temperature-sensitive alleles of either the DCP1 or the DCP2 genes. In these cases, deletion of EDC3 caused a synergistic mRNA-decapping defect at the permissive temperatures. The edc3Δ had no effect when combined with the lsm1Δ, dhh1Δ, or pat1Δ mutations, which appear to affect an early step in the decapping pathway. This suggests that Edc3p specifically affects the function of the decapping enzyme per se. Consistent with a functional role in decapping, GFP-tagged Edc3p localizes to cytoplasmic foci involved in mRNA decapping referred to as P-bodies. These results identify Edc3p as a new protein involved in the decapping reaction." @default.
• W4251440314 created "2022-05-12" @default.
• W4251440314 creator A5008589792 @default.
• W4251440314 creator A5014796446 @default.
• W4251440314 date "2004-02-01" @default.
• W4251440314 modified "2023-09-27" @default.
• W4251440314 title "Identification of Edc3p as an Enhancer of mRNA Decapping in<i>Saccharomyces cerevisiae</i>" @default.
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• W4251440314 doi "https://doi.org/10.1093/genetics/166.2.729" @default.
• W4251440314 hasPublicationYear "2004" @default.
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