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- W4251459845 abstract "Objectives: To compare the local tolerability, adhesion and estradiol delivery of a 5-cm2 transdermal patch (Estradot®, Novartis Pharmaceuticals, Basel, Switzerland) and a 12.5-cm2 patch (Climara®, Berlex Laboratories, Wayne, NJ, USA). Methods: This was an open-label, randomized, intrapatient, comparative study. One hundred healthy postmenopausal women applied the 50 μg/day 5-cm2 patch and the 12.5-cm2 patch concurrently for 7 days; safety and tolerability were assessed. Twelve women continued to apply the 5-cm2 and 12.5-cm2 patches separately for 7 days in a two-way cross-over study, to investigate the reproducibility of estradiol delivery. Results: The proportion of subjects with a clinically significant erythema score was higher with the 12.5-cm2 patch. The 5-cm2 patch had a significantly lower incidence of very slight erythema than the larger patch (21.4% vs. 32.3%; p = 0.0028). Overall erythema scores were 0.22 and 0.41, respectively. More 5-cm2 patches had > 90% adherence than the 12.5-cm2 patches (87.5% vs. 82.0%, not significant) and fewer became detached (0.5% vs. 3.0%). Both the patches showed reproducible delivery of estradiol. Conclusion: The 5-cm2 patch was associated with less skin irritation and better adherence than the 12.5-cm2 patch, although the majority of the differences were not significant. The 5-cm2 patch was well tolerated and showed reproducible estradiol delivery, as did the 12.5-cm2 patch." @default.
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- W4251459845 date "2002-01-01" @default.
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- W4251459845 title "Comparative study to evaluate skin irritation and adhesion of Estradot®and Climara®in healthy postmenopausal women" @default.
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- W4251459845 doi "https://doi.org/10.1080/cmt.5.4.383.389" @default.
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