Matches in SemOpenAlex for { <https://semopenalex.org/work/W4251465248> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4251465248 endingPage "10" @default.
- W4251465248 startingPage "1" @default.
- W4251465248 abstract "Pyrazole and 4-methylpyrazole (4-MP) are effective inhibitors of alcohol dehydrogenase (ADH) activity in mammals both in vivo and in vitro. 4-MP has a tenfold higher inhibition specificity compared with pyrazole. Pyrazole proved a teratogenic compound in Drosophila melanogaster. Treatment of third instar larvae of D. melanogaster with pyrazole, in contrast with 4-MP, produced an increase in the number of dorsocentral and scutellar macrochaetae and wing-notches in the adult fly. A large difference in the penetrance of terata in males and females was observed. Similar effects were observed in flies lacking ADH molecules. The teratogenicity of pyrazole must be due to disturbance of processes other than ADH inhibition. Synergistic effects were observed between pyrazole and methoxyacetic acid (MAA), an in vitro inhibitor of sarcosine dehydrogenase activity. Each of these compounds, when fed to early third instar larvae, produced terata resembling the Notch mutant of D. melanogaster. © 1995 Wiley-Liss, Inc." @default.
- W4251465248 created "2022-05-12" @default.
- W4251465248 creator A5009507749 @default.
- W4251465248 date "1995-01-01" @default.
- W4251465248 modified "2023-09-27" @default.
- W4251465248 title "Differences in teratogenic and toxic properties of alcohol dehydrogenase inhibitors pyrazole and 4-methylpyrazole inDrosophila melanogaster: I. ADH allozymes in variable genetic backgrounds" @default.
- W4251465248 cites W116494028 @default.
- W4251465248 cites W1871729829 @default.
- W4251465248 cites W1969355293 @default.
- W4251465248 cites W1977477967 @default.
- W4251465248 cites W1992310556 @default.
- W4251465248 cites W2007077785 @default.
- W4251465248 cites W2020637536 @default.
- W4251465248 cites W2022905021 @default.
- W4251465248 cites W2023156098 @default.
- W4251465248 cites W2026566846 @default.
- W4251465248 cites W2027684589 @default.
- W4251465248 cites W2028711149 @default.
- W4251465248 cites W2031003809 @default.
- W4251465248 cites W2034440417 @default.
- W4251465248 cites W2035255549 @default.
- W4251465248 cites W2045467984 @default.
- W4251465248 cites W2061182731 @default.
- W4251465248 cites W2068520629 @default.
- W4251465248 cites W2071802718 @default.
- W4251465248 cites W2074153393 @default.
- W4251465248 cites W2075567827 @default.
- W4251465248 cites W2086474904 @default.
- W4251465248 cites W2095025243 @default.
- W4251465248 cites W2095181192 @default.
- W4251465248 cites W2136974033 @default.
- W4251465248 cites W2282045603 @default.
- W4251465248 cites W2318381323 @default.
- W4251465248 cites W2435472205 @default.
- W4251465248 cites W91184214 @default.
- W4251465248 doi "https://doi.org/10.1002/tcm.1770150102" @default.
- W4251465248 hasPublicationYear "1995" @default.
- W4251465248 type Work @default.
- W4251465248 citedByCount "2" @default.
- W4251465248 crossrefType "journal-article" @default.
- W4251465248 hasAuthorship W4251465248A5009507749 @default.
- W4251465248 hasConcept C104317684 @default.
- W4251465248 hasConcept C185592680 @default.
- W4251465248 hasConcept C207001950 @default.
- W4251465248 hasConcept C2776998849 @default.
- W4251465248 hasConcept C2777344606 @default.
- W4251465248 hasConcept C2777379243 @default.
- W4251465248 hasConcept C2777682936 @default.
- W4251465248 hasConcept C2780104201 @default.
- W4251465248 hasConcept C2780161600 @default.
- W4251465248 hasConcept C54355233 @default.
- W4251465248 hasConcept C55493867 @default.
- W4251465248 hasConcept C71240020 @default.
- W4251465248 hasConcept C86803240 @default.
- W4251465248 hasConcept C98274493 @default.
- W4251465248 hasConceptScore W4251465248C104317684 @default.
- W4251465248 hasConceptScore W4251465248C185592680 @default.
- W4251465248 hasConceptScore W4251465248C207001950 @default.
- W4251465248 hasConceptScore W4251465248C2776998849 @default.
- W4251465248 hasConceptScore W4251465248C2777344606 @default.
- W4251465248 hasConceptScore W4251465248C2777379243 @default.
- W4251465248 hasConceptScore W4251465248C2777682936 @default.
- W4251465248 hasConceptScore W4251465248C2780104201 @default.
- W4251465248 hasConceptScore W4251465248C2780161600 @default.
- W4251465248 hasConceptScore W4251465248C54355233 @default.
- W4251465248 hasConceptScore W4251465248C55493867 @default.
- W4251465248 hasConceptScore W4251465248C71240020 @default.
- W4251465248 hasConceptScore W4251465248C86803240 @default.
- W4251465248 hasConceptScore W4251465248C98274493 @default.
- W4251465248 hasIssue "1" @default.
- W4251465248 hasLocation W42514652481 @default.
- W4251465248 hasOpenAccess W4251465248 @default.
- W4251465248 hasPrimaryLocation W42514652481 @default.
- W4251465248 hasRelatedWork W1585914798 @default.
- W4251465248 hasRelatedWork W1972884197 @default.
- W4251465248 hasRelatedWork W1996938821 @default.
- W4251465248 hasRelatedWork W2029777364 @default.
- W4251465248 hasRelatedWork W2034440417 @default.
- W4251465248 hasRelatedWork W2050433310 @default.
- W4251465248 hasRelatedWork W2068268417 @default.
- W4251465248 hasRelatedWork W2116152399 @default.
- W4251465248 hasRelatedWork W2315331765 @default.
- W4251465248 hasRelatedWork W4251465248 @default.
- W4251465248 hasVolume "15" @default.
- W4251465248 isParatext "false" @default.
- W4251465248 isRetracted "false" @default.
- W4251465248 workType "article" @default.