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- W4251465269 abstract "A chimeric monoclonal antibody (consisting of murine and human components) of the IgG1 class, which binds specifically to human TNFα. It is administered by intravenous infusions at regular intervals in doses of 3 mg/kg (rheumatoid arthritis), 5 mg/kg (ankylosing spondylitis, psoriatic arthritis or psoriasis, and Crohn’s disease) over 2 hours. After the initial infusion, subsequent infusions are administered after two weeks, six weeks after the first dose, and then all subsequent doses are administered every eight weeks. The serum concentrations of infliximab are more sustained with concomitantly administered methotrexate (MTX; a fixed oral dose of 15–25 mg/week). The co-administration of infliximab and MTX (or an alternative immunosuppressant drug if MTX is not tolerated) not only significantly suppresses the inflammatory activity of rheumatoid arthritis, but also seems to improve the immunological tolerance of infliximab.KeywordsSystemic Lupus ErythematosusInflammatory Bowel DiseaseAnkylose SpondylitisPsoriatic ArthritisGlandular FeverThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W4251465269 created "2022-05-12" @default.
- W4251465269 date "2009-01-01" @default.
- W4251465269 modified "2023-09-27" @default.
- W4251465269 title "Infliximab (Remicade)" @default.
- W4251465269 doi "https://doi.org/10.1007/978-3-211-79280-3_566" @default.
- W4251465269 hasPublicationYear "2009" @default.
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