FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4251511683> ?p ?o ?g. }

• W4251511683 endingPage "10325" @default.
• W4251511683 startingPage "10322" @default.
• W4251511683 abstract "Journal of Cellular and Molecular MedicineVolume 25, Issue 21 p. 10322-10325 CORRIGENDUMOpen Access This article corrects the following: Monotropein promotes angiogenesis and inhibits oxidative stress-induced autophagy in endothelial progenitor cells to accelerate wound healing Chenggui Wang, Cong Mao, Yiting Lou, Jianxiang Xu, Qingqing Wang, Zengjie Zhang, Qian Tang, Xiaolei Zhang, Huazi Xu, Yongzeng Feng, Volume 22Issue 3Journal of Cellular and Molecular Medicine pages: 1583-1600 First Published online: December 26, 2017 First published: 07 November 2021 https://doi.org/10.1111/jcmm.16995AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat In Chenggui Wang,1 the published version contains errors in Figures 1D, E, 3B, F, H, 6E and 7E. The correct figures are shown below. All results and conclusions remain intact. The authors apologize for the errors. FIGURE 1Open in figure viewerPowerPoint Effect of Mtp on cellular proliferation, migration, recruitment and tube formation of BM-EPCs. (A) Cell proliferation results of BM-EPCs treated with different concentrations of Mtp for 48 h. Cells proliferated evidently faster after Mtp treatment; (B, C) Cell migration regulated by Mtp treatments. Scratch assay showed that EPCs migrated evidently faster in Mtp-treated group (scale bar: 200 μm); Data are presented as mean ± SD, & p < 0.05 versus the control group, # p < 0.05 versus the 1 μM Mtp-treated group, % p < 0.05 versus the 10 μM Mtp-treated group; (D, F) Transwell chemotaxis assay results of BM-EPCs with different treatments. BM-EPCs were treated with PBS (control), 50 ng/ml bFGF and 1, 10 and 100 µM Mtp in the lower chamber for 3 h incubation. Numbers of migrated cells were quantified by counting cells in 10 random fields using an inverted microscope (scale bar: 50 μm). The migration of BM-EPCs was enhanced after Mtp treatment; (E, G) In-vitro tube formation results of BM-EPCs treated by Mtp. Cells were grown on MatrigelTM for 6 h under normal growth conditions, five independent fields were assessed for each well and the number of tubes were determined (scale bar: 100 μm). The tube formation ability of BM-EPCs was improved after Mtp treatment. n = 3 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.005 and ****p < 0.001 versus the indicated group FIGURE 3Open in figure viewerPowerPoint mTOR pathway regulates chemotaxis and capillary-tube formation capacity of BM-EPCs. (A) Gene expression of VEGF, KDR, PECAM-1 and VE-cadherin in Mtp-treated BM-EPCs. Cells were cultivated with 1, 10 and 100 µM Mtp or bFGF (50 ng/ml) for 48 h and treated with 100 µM Mtp for 24, 48, 72 and 96 h. Gene levels were assessed via qRT-PCR and normalized to β-actin, related gene were upregulated by Mtp at 48 h or less; (B, C, D, E) Western blot analysis of p-mTOR, p-p70S6K, p-4EBP1, SQSTM1/P62 and Beclin-1 in different dose of Mtp-treated BM-EPCs for 48 h. Mtp evidently increased mTOR pathway proteins and decreased autophagy level; (F, G) Cell chemotaxis regulated by the treatments of rapamycin and/or Mtp. BM-EPCs were treated with 100 nM rapamycin for 2 h prior to treatment with Mtp for 48 h. The numbers of migrated cells were quantified by performing cell counts of 10 random fields (scale bar: 50 μm); (H, I) In-vitro tube formation results of BM-EPCs treated by rapamycin and/or Mtp (scale bar: 100 μm); The densitometric analysis of all Western blot bands was normalized to the total proteins or GAPDH. n = 3 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.005 and ****p < 0.001 versus the indicated group FIGURE 6Open in figure viewerPowerPoint Mtp provides cellular protection against apoptosis in BM-EPCs via mTOR signalling pathways. (A, B) Immunofluorescence staining images and intensity of LC3 positive autophagic vesicles (scale bar: 50 μm). LC3 autophagic vesicles were significantly decreased by Mtp pretreatment; (C–H) Protein levels of p-mTOR, p-p70S6K, p-4EBP1, SQSTM1/P62, Beclin-1 and LC3-II, Cleaved-caspase3, Bax, Bcl-2, Cytochrome C, Caspase9 in BM-EPCs treated with 100 nM rapamycin for 2 h, 100 µM Mtp for 48 h and TBHP for 3 h; (I) Cell viability results by CCK-8 test of BM-EPCs treated with 100 nM rapamycin for 2 h, 100 µM Mtp for 48 h and TBHP for 3 h. Cell viability was evidently increased by the Mtp pretreatment. The densitometric analysis of all Western blot bands was normalized to the total proteins or GAPDH. n = 3 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.005 and ****p < 0.001 versus the indicated group FIGURE 7Open in figure viewerPowerPoint Suppressed of AMPK by Mtp attenuates oxidative stress-mediated cell apoptosis and autophagy. (A, B) Western blot analysis of expression of p-AMPK in different dose of Mtp treatment. BM-EPCs were treated with 1, 10, 100 μM Mtp. The protein expression of p-AMPK was decreased after Mtp treatment; (C, D) Western blot analysis of expression of p-AMPK after Mtp pretreatment. Cells pretreated with 100 μM Mtp followed by TBHP stimulation. Mtp-reduced p-AMPK protein expression of BM-EPCs induced by TBHP; (E–O) Western blot analysis of expression of p-AMPK, p-mTOR, cleaved-caspase3, Bax, Bcl-2, caspase9, SQSTM1/P62 and LC3-II. Cells were pretreated with 5 µM compound C or 1 mM AICAR for 2 h followed by 100 µM Mtp for 48 h and incubated with TBHP for 3 h. (P) Cell Counting Kit-8 (CCK-8) results of BM-EPCs were treated under the same conditions as above. Cell viability was significantly increased by Cpd C treatment. The densitometric analysis of all Western blot band intensities was normalized to the total proteins or GAPDH. n = 3 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.005 and ****p < 0.001 versus the indicated group REFERENCE 1Wang C, Mao C, Lou Y, et al. Monotropein promotes angiogenesis and inhibits oxidative stress-induced autophagy in endothelial progenitor cells to accelerate wound healing. J Cell Mol Med. 2018; 22: 1583- 1600. doi:10.1111/jcmm.13434. Volume25, Issue21November 2021Pages 10322-10325 FiguresReferencesRelatedInformation" @default.
• W4251511683 created "2022-05-12" @default.
• W4251511683 date "2021-11-01" @default.
• W4251511683 modified "2023-09-24" @default.
• W4251511683 title " " @default.
• W4251511683 cites W2776618650 @default.
• W4251511683 doi "https://doi.org/10.1111/jcmm.16995" @default.
• W4251511683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34747104" @default.
• W4251511683 hasPublicationYear "2021" @default.
• W4251511683 type Work @default.
• W4251511683 citedByCount "0" @default.
• W4251511683 crossrefType "journal-article" @default.
• W4251511683 hasBestOaLocation W42515116831 @default.
• W4251511683 hasConcept C71924100 @default.
• W4251511683 hasConcept C86803240 @default.
• W4251511683 hasConceptScore W4251511683C71924100 @default.
• W4251511683 hasConceptScore W4251511683C86803240 @default.
• W4251511683 hasIssue "21" @default.
• W4251511683 hasLocation W42515116831 @default.
• W4251511683 hasLocation W42515116832 @default.
• W4251511683 hasLocation W42515116833 @default.
• W4251511683 hasLocation W42515116834 @default.
• W4251511683 hasOpenAccess W4251511683 @default.
• W4251511683 hasPrimaryLocation W42515116831 @default.
• W4251511683 hasRelatedWork W1506200166 @default.
• W4251511683 hasRelatedWork W1995515455 @default.
• W4251511683 hasRelatedWork W2048182022 @default.
• W4251511683 hasRelatedWork W2080531066 @default.
• W4251511683 hasRelatedWork W2604872355 @default.
• W4251511683 hasRelatedWork W2748952813 @default.
• W4251511683 hasRelatedWork W2899084033 @default.
• W4251511683 hasRelatedWork W3031052312 @default.
• W4251511683 hasRelatedWork W3032375762 @default.
• W4251511683 hasRelatedWork W3108674512 @default.
• W4251511683 hasVolume "25" @default.
• W4251511683 isParatext "false" @default.
• W4251511683 isRetracted "false" @default.
• W4251511683 workType "article" @default.