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- W4251682610 abstract "Abstract Background Pantothenic acid deficiency (PAD) results in growth depression and intestinal hypofunction of animals. The underlying mechanisms, however, remain to be established and an overview of molecular alterations is still lacking. We investigated intestinal mucosal proteome changes induced by PAD in ducks to explain its effects on growth and intestine. Methods A total of 128 one-day-old Pekin ducks were divided into two groups, with 8 replicates and 8 birds per replicate. All the ducks were fed either a PAD or a pantothenic acid adequate (control, CON) diet for 16 days. Results High mortality, growth retardation, fasting hypoglycemia, reduced plasma insulin, and oxidative stress were observed in the PAD group compared to the CON group. Furthermore, PAD induced morphological alterations of the small intestine indicated by reduced villus height and villus surface area of duodenum, jejunum, and ileum. The duodenum mucosal proteome of ducks showed that 198 proteins were upregulated and 223 proteins were downregulated (> 1.5-fold change) in the PAD group compared to those in the CON group. Pathway analysis of these proteins exhibited the suppression of glycolysis and gluconeogenesis, fatty acid beta oxidation, tricarboxylic acid cycle, oxidative phosphorylation, oxidative stress, and intestinal absorption in the PAD group, indicating impaired energy generation and abnormal intestinal absorption. We also show that nine out of eleven proteins involved in regulation of actin cytoskeleton were upregulated by PAD, probably indicates reduced intestinal integrity. Conclusion PAD leads to growth depression and intestinal hypofunction of ducks, which are associated with impaired in energy generation, abnormal intestinal absorption, and regulation of actin cytoskeleton processes. These findings contribute to our understanding of the mechanisms of intestinal mucosa metabolic disorders due to PAD." @default.
- W4251682610 created "2022-05-12" @default.
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- W4251682610 date "2020-06-25" @default.
- W4251682610 modified "2023-10-18" @default.
- W4251682610 title "Severe pantothenic acid deficiency induces alterations in the intestinal mucosal proteome of starter Pekin ducks" @default.
- W4251682610 doi "https://doi.org/10.21203/rs.3.rs-37755/v1" @default.
- W4251682610 hasPublicationYear "2020" @default.
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