Matches in SemOpenAlex for { <https://semopenalex.org/work/W4251698116> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W4251698116 endingPage "E8" @default.
- W4251698116 startingPage "E8" @default.
- W4251698116 abstract "Sir, There are a number of studies that suggest that statins may be protective against prostate cancer. Recently, Farwell et al. 1 reported a statistically significant reduced risk of total and high-grade prostate cancer in statin users from a Veterans Affairs population. We thank Goldstein and Mascitelli for their comprehensive description of a contrasting viewpoint wherein statins may promote prostate carcinogenesis. In the present study 2, we found that patients who were on a statin were at a statistically significant increased risk for biochemical recurrence (BCR) after radical prostatectomy. We think that this may have been due to a masking effect of statins on the true aggressiveness of the disease at the time of diagnosis. This was supported by the finding that statin users had a lower PSA level before surgery but were more likely to experience BCR. Goldstein and Mascitelli theorise that statin use in conjunction with surgery may promote angiogenesis and immunosuppression thereby promoting cancer and leading to an increased risk of BCR. While this hypothesis is interesting, we have no data to support this mechanism of action in our study 2 and therefore cannot conclude that statins play a direct tumorigenic role from a molecular standpoint. We think that the data on statins and prostate cancer remain controversial. Furthermore, Papadopoulus et al. 3 describe several molecular mechanisms by which statins may both prevent and promote prostate cancer. We encourage further research and emphasize that despite some evidence for the anti-cancer effects of statins, well-designed studies are needed before recommending statins as chemoprevention or adjunctive therapy in prostate cancer." @default.
- W4251698116 created "2022-05-12" @default.
- W4251698116 creator A5069667887 @default.
- W4251698116 date "2011-07-01" @default.
- W4251698116 modified "2023-09-30" @default.
- W4251698116 title "REPLY" @default.
- W4251698116 cites W1600466695 @default.
- W4251698116 cites W2015413739 @default.
- W4251698116 cites W2147671638 @default.
- W4251698116 doi "https://doi.org/10.1111/j.1464-410x.2011.10449_2.x" @default.
- W4251698116 hasPublicationYear "2011" @default.
- W4251698116 type Work @default.
- W4251698116 citedByCount "0" @default.
- W4251698116 crossrefType "journal-article" @default.
- W4251698116 hasAuthorship W4251698116A5069667887 @default.
- W4251698116 hasConcept C121608353 @default.
- W4251698116 hasConcept C126322002 @default.
- W4251698116 hasConcept C143998085 @default.
- W4251698116 hasConcept C2776839432 @default.
- W4251698116 hasConcept C2779134260 @default.
- W4251698116 hasConcept C2779466945 @default.
- W4251698116 hasConcept C2780192828 @default.
- W4251698116 hasConcept C2780252810 @default.
- W4251698116 hasConcept C2908647359 @default.
- W4251698116 hasConcept C71924100 @default.
- W4251698116 hasConcept C99454951 @default.
- W4251698116 hasConceptScore W4251698116C121608353 @default.
- W4251698116 hasConceptScore W4251698116C126322002 @default.
- W4251698116 hasConceptScore W4251698116C143998085 @default.
- W4251698116 hasConceptScore W4251698116C2776839432 @default.
- W4251698116 hasConceptScore W4251698116C2779134260 @default.
- W4251698116 hasConceptScore W4251698116C2779466945 @default.
- W4251698116 hasConceptScore W4251698116C2780192828 @default.
- W4251698116 hasConceptScore W4251698116C2780252810 @default.
- W4251698116 hasConceptScore W4251698116C2908647359 @default.
- W4251698116 hasConceptScore W4251698116C71924100 @default.
- W4251698116 hasConceptScore W4251698116C99454951 @default.
- W4251698116 hasIssue "2" @default.
- W4251698116 hasLocation W42516981161 @default.
- W4251698116 hasOpenAccess W4251698116 @default.
- W4251698116 hasPrimaryLocation W42516981161 @default.
- W4251698116 hasRelatedWork W1558847819 @default.
- W4251698116 hasRelatedWork W1899936169 @default.
- W4251698116 hasRelatedWork W1985168450 @default.
- W4251698116 hasRelatedWork W2006505155 @default.
- W4251698116 hasRelatedWork W2079486447 @default.
- W4251698116 hasRelatedWork W2132373402 @default.
- W4251698116 hasRelatedWork W2790071061 @default.
- W4251698116 hasRelatedWork W3187635025 @default.
- W4251698116 hasRelatedWork W4235380988 @default.
- W4251698116 hasRelatedWork W2129613843 @default.
- W4251698116 hasVolume "108" @default.
- W4251698116 isParatext "false" @default.
- W4251698116 isRetracted "false" @default.
- W4251698116 workType "article" @default.