Matches in SemOpenAlex for { <https://semopenalex.org/work/W4251705088> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4251705088 endingPage "421" @default.
- W4251705088 startingPage "413" @default.
- W4251705088 abstract "Effect of (±)-methyl 3-ethyl-2,3,3a,4-tetrahydro-1H-indolo[3,2,1 -de] [1,5] naphthyridine-6-carboxylate hydrochloride (OM-853), a new vincamine analogue, on the metabolism and function of cerebral 5-hydroxytryptamine (5-HT) neurons was investigated using male Wistar rats. The single administration of OM-853 (200 mg/kg, p.o.) induced the facilitation of metabolic turnover of 5-HT in various brain areas except the cerebral cortex, pons-medulla and cerebellum. In vitro addition of OM-853 inhibited the uptake of [14C]5-HT in striatal slices only at a high concentration (10–4 M). On the other hand, a low concentration of OM-853 (10–8–10–6 M) induced the increase of the spontaneous and high K+ (30 mM)-evoked releases of [14C]5-HT from striatal slices. OM-853 had more potent inhibitory effect on the binding of [3H]8-hydroxy-2-(di-n-propylamino)tetralin (8-hydroxy DPAT) to 5-HT1A receptors and/or 5-HT autoreceptors than that of [3H]-ketanserin to 5-HT2 receptors. The stimulatory effect of OM-853 (10–7 M) on [14C]5-HT release was antagonized by 10–7 M 8-hydroxy DPAT, which is known to act at presynaptic 5-HT autoreceptors as an agonist. These results suggest that OM-853 may induce facilitation of 5-HT turnover by enhancing 5-HT release, probably via the inhibition of presynaptic 5-HT autoreceptor." @default.
- W4251705088 created "2022-05-12" @default.
- W4251705088 creator A5008239997 @default.
- W4251705088 creator A5013658646 @default.
- W4251705088 creator A5027191467 @default.
- W4251705088 creator A5074556467 @default.
- W4251705088 date "1989-01-01" @default.
- W4251705088 modified "2023-09-25" @default.
- W4251705088 title "Effect of (±)-Methyl 3-Ethyl-2,3,3a,4-Tetrahydro-1H-Indolo-[3,2,1-de] [1,5] Naphthyridine-6-Carboxylate Hydrochloride (OM-853), a New Vincamine Analogue, on the Metabolism and Function of Cerebral Serotonergic Neurons" @default.
- W4251705088 cites W1525338767 @default.
- W4251705088 cites W1684853394 @default.
- W4251705088 cites W1775749144 @default.
- W4251705088 cites W1966227815 @default.
- W4251705088 cites W1981818755 @default.
- W4251705088 cites W1986438238 @default.
- W4251705088 cites W1989788228 @default.
- W4251705088 cites W1994441778 @default.
- W4251705088 cites W2010120109 @default.
- W4251705088 cites W2032641618 @default.
- W4251705088 cites W2041981970 @default.
- W4251705088 cites W2059172718 @default.
- W4251705088 cites W2062359923 @default.
- W4251705088 cites W2066607176 @default.
- W4251705088 cites W2066663898 @default.
- W4251705088 cites W2089851628 @default.
- W4251705088 cites W2092611219 @default.
- W4251705088 cites W2110765139 @default.
- W4251705088 cites W2127895648 @default.
- W4251705088 cites W2145976963 @default.
- W4251705088 cites W2158907779 @default.
- W4251705088 doi "https://doi.org/10.1016/s0021-5198(19)43052-7" @default.
- W4251705088 hasPublicationYear "1989" @default.
- W4251705088 type Work @default.
- W4251705088 citedByCount "0" @default.
- W4251705088 crossrefType "journal-article" @default.
- W4251705088 hasAuthorship W4251705088A5008239997 @default.
- W4251705088 hasAuthorship W4251705088A5013658646 @default.
- W4251705088 hasAuthorship W4251705088A5027191467 @default.
- W4251705088 hasAuthorship W4251705088A5074556467 @default.
- W4251705088 hasBestOaLocation W42517050881 @default.
- W4251705088 hasConcept C126322002 @default.
- W4251705088 hasConcept C134018914 @default.
- W4251705088 hasConcept C170493617 @default.
- W4251705088 hasConcept C185592680 @default.
- W4251705088 hasConcept C2775864247 @default.
- W4251705088 hasConcept C2776460385 @default.
- W4251705088 hasConcept C2777785214 @default.
- W4251705088 hasConcept C2778938600 @default.
- W4251705088 hasConcept C53910766 @default.
- W4251705088 hasConcept C55493867 @default.
- W4251705088 hasConcept C71924100 @default.
- W4251705088 hasConcept C8439214 @default.
- W4251705088 hasConcept C86803240 @default.
- W4251705088 hasConcept C98274493 @default.
- W4251705088 hasConceptScore W4251705088C126322002 @default.
- W4251705088 hasConceptScore W4251705088C134018914 @default.
- W4251705088 hasConceptScore W4251705088C170493617 @default.
- W4251705088 hasConceptScore W4251705088C185592680 @default.
- W4251705088 hasConceptScore W4251705088C2775864247 @default.
- W4251705088 hasConceptScore W4251705088C2776460385 @default.
- W4251705088 hasConceptScore W4251705088C2777785214 @default.
- W4251705088 hasConceptScore W4251705088C2778938600 @default.
- W4251705088 hasConceptScore W4251705088C53910766 @default.
- W4251705088 hasConceptScore W4251705088C55493867 @default.
- W4251705088 hasConceptScore W4251705088C71924100 @default.
- W4251705088 hasConceptScore W4251705088C8439214 @default.
- W4251705088 hasConceptScore W4251705088C86803240 @default.
- W4251705088 hasConceptScore W4251705088C98274493 @default.
- W4251705088 hasIssue "3" @default.
- W4251705088 hasLocation W42517050881 @default.
- W4251705088 hasOpenAccess W4251705088 @default.
- W4251705088 hasPrimaryLocation W42517050881 @default.
- W4251705088 hasRelatedWork W1895691359 @default.
- W4251705088 hasRelatedWork W1986965950 @default.
- W4251705088 hasRelatedWork W2004959129 @default.
- W4251705088 hasRelatedWork W2007471305 @default.
- W4251705088 hasRelatedWork W2008086188 @default.
- W4251705088 hasRelatedWork W2048991606 @default.
- W4251705088 hasRelatedWork W2054184534 @default.
- W4251705088 hasRelatedWork W2066518179 @default.
- W4251705088 hasRelatedWork W2070551380 @default.
- W4251705088 hasRelatedWork W2789439376 @default.
- W4251705088 hasVolume "49" @default.
- W4251705088 isParatext "false" @default.
- W4251705088 isRetracted "false" @default.
- W4251705088 workType "article" @default.