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- W4251736100 abstract "Recognition of the relationship of the administration of certain compounds, notably amidopyrine, to the occurrence of granulocytopenia<sup>1</sup>has led to studies of the effects of such substances on circulating granulocytes. The results of animal experiments have for the most part proved equivocal. Administration of drugs suspected of being implicated as etiologic factors has had little detectable effect in most cases, even when the substances were given in large amounts. This is not surprising in view of the infrequency with which granulocytopenia occurs clinically, despite the large quantities of amidopyrine and similar drugs employed. The attention of investigators has therefore been diverted from study of the circulating blood to observation of changes in the bone marrow. Miller<sup>2</sup>of the Rockefeller Institute administered amidopyrine in daily doses of 0.3 Gm. per kilogram of body weight by mouth to sixteen dogs. With this large dose no marked decrease in circulating granulocytes" @default.
- W4251736100 created "2022-05-12" @default.
- W4251736100 date "1935-08-10" @default.
- W4251736100 modified "2023-09-30" @default.
- W4251736100 title "INHIBITION OF LEUKOPOIESIS BY CERTAIN DRUGS" @default.
- W4251736100 doi "https://doi.org/10.1001/jama.1935.02760320041016" @default.
- W4251736100 hasPublicationYear "1935" @default.
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