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• W4251760134 abstract "THROMBOCYTOPENIA, defined as a platelet count less than 150 × 109/L, is extremely common in cardiac surgery patients. Whereas noncardiac surgery is the most common cause of secondary thrombocytosis, cardiopulmonary bypass (CPB) causes an abrupt decrease in platelet count. 1 Greisshammer M. Bangerter M. Sauer T. et al. Etiology and clinical significance of thrombocytosis Analysis of 732 patients with an elevated platelet count. J Intern Med. 1999; 245: 295-300 Crossref PubMed Scopus (216) Google Scholar , 2 Martin J.F. Daniel T.D. Towbridge E.A. Acute and chronic changes in platelet volume and count after cardiopulmonary bypass-induced thrombocytopenia in man. Thromb Haemost. 1987; 57: 55-58 PubMed Google Scholar Causes of this include but are not limited to mechanical disruption by the extracorporeal circuit (or intraaortic balloon pump), hemodilution, sepsis, and heparin-induced thrombocytopenia and thrombosis. While the platelet count nadir tends to occur around postoperative day 2 to 3, as many as 10% of patients will continue to have a platelet count of less than 50% of baseline on the fourth postoperative day. 3 Matthai W.H. Thrombocytopenia in cardiovascular patients. Chest. 2005; 127: 46S-52S Crossref PubMed Scopus (46) Google Scholar , 4 Warkentin T.E. Greinacher A. Heparin-induced thrombocytopenia and cardiac surgery. Ann Thorac Surg. 2003; 76: 2121-2131 Abstract Full Text Full Text PDF PubMed Scopus (180) Google Scholar The most common pharmacologic cause of this prolonged thrombocytopenia is heparin. 5 Bonfiglio M.F. Traeger S.M. Kier K.L. et al. Thrombocytopenia in intensive care patients A comprehensive analysis of risk factors in 314 patients. Ann Pharmacother. 1995; 29: 835-842 PubMed Google Scholar Other frequently administered medications that have been associated with thrombocytopenia include digoxin, amiodarone, penicillins, cephalosporins, sulfonamides, vancomycin, gentamicin, diazepam, valproic acid, tegretol, cimetidine, and ranitidine. 6 George J.N. Raskob G.E. Shah S.R. et al. Drug-induced thrombocytopenia A systematic review of published case reports. Ann Intern Med. 1998; 129: 886-890 Crossref PubMed Google Scholar" @default.
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• W4251760134 date "2006-02-01" @default.
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• W4251760134 title "Con: Should Aspirin Be Continued After Cardiac Surgery in the Setting of Thrombocytopenia?" @default.
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• W4251760134 doi "https://doi.org/10.1053/j.jvca.2005.10.007" @default.
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