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- W4251796125 abstract "Transgenic mice carrying the phosphoenolpyruvate carboxykinase promoter region-human growth hormone (PEPCK-hGH) fusion gene are characterized by accelerated growth and plasma hGH levels ranging from 100 to 700 ng/ml. Both sexes are fertile, in contrast to previous findings in metallothionein-I/hGH transgenic mice in which females are sterile, apparently due to luteal failure. Virgin transgenic PEPCK/hGH females from this line produce milk and can successfully raise foster litters to weaning. We conclude that the life-long presence of very large amounts of hGH in the circulation is compatible with ovulation, can override the effects of hGH-induced suppression of endogenous PRL release, and can support full lactation in animals that have not been primed by hormonal changes associated with pregnancy." @default.
- W4251796125 created "2022-05-12" @default.
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- W4251796125 date "1992-07-01" @default.
- W4251796125 modified "2023-10-18" @default.
- W4251796125 title "Transgenic female mice with high human growth hormone levels are fertile and capable of normal lactation without having been pregnant" @default.
- W4251796125 doi "https://doi.org/10.1210/en.131.1.536" @default.
- W4251796125 hasPublicationYear "1992" @default.
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