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- W4251801841 abstract "Uric acid is present in human plasma in relatively high concentrations and is considered to be a natural physiological antioxidant. We have earlier shown that in the presence of Cu(II) and molecular oxygen, uric acid causes strand breakage in DNA. In this article, we show that uric acid fluorescence is quenched by addition of DNA, indicating the formation of uric acid-DNA complex. Uric acid-Cu(II)-mediated DNA strand scission is capable of bacteriophage inactivation and such inactivation is mediated through reduction of Cu(II) to Cu(I) and the generation of oxygen-derived radicals. It is indicated that the DNA breakage is repaired in E. coli and involves the repair of DNA polymerase. © 1996 John Wiley & Sons, Inc." @default.
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- W4251801841 date "1996-01-01" @default.
- W4251801841 modified "2023-10-14" @default.
- W4251801841 title "DNA breakage by uric acid and Cu(II): Binding of uric acid to DNA and biological activity of the reaction" @default.
- W4251801841 doi "https://doi.org/10.1002/(sici)1522-7146(1996)11:2<67::aid-jbt3>3.3.co;2-z" @default.
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