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- W4251835378 abstract "Abstract Background : Osteosarcoma (OS) is the most common malignant tumor of bone which was featured with osteoid or immature bone produced by the malignant cells, and biomarkers are urgently needed to identify patients with this aggressive disease. Methods : We downloaded gene expression profiles from Gene Expression Omnibus (GEO) and The Therapeutically Applicable Research to Generate Effective Treatments (TARGET) datasets for OS, respectively, and performed weighted gene co-expression network analysis (WGCNA) to identify the key module. Whereafter, functional annotation and Gene Set Enrichment Analysis (GSEA) demonstrated the relationships between target genes and OS. Results : In this study, we discovered four key genes – ALOX5AP, HLA-DMB, HLA-DRA and SPINT2 as new prognostic markers and confirmed their relationship with OS metastasis in the validation set. Conclusions : Overall, our work may shed light on the roles of ALOX5AP, HLA-DMB, HLA-DRA and SPINT2, thus providing valuable clues to investigate the metastasis of OS and corroborating the potential clinical application value of the 4-gene signature to some extent." @default.
- W4251835378 created "2022-05-12" @default.
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- W4251835378 date "2020-01-14" @default.
- W4251835378 modified "2023-10-17" @default.
- W4251835378 title "Expression Profile Analysis Identifies Key Genes as Prognostic Markers for Metastasis of Osteosarcoma" @default.
- W4251835378 doi "https://doi.org/10.21203/rs.2.20786/v1" @default.
- W4251835378 hasPublicationYear "2020" @default.
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