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• W4251868075 abstract "Aging and associated pathologies such as Alzheimer's disease (AD) are major public health challenges. Implementation of new animal models and associated biomarkers monitoring aging processes are critical to better evaluate future therapies. In humans, FDG-PET is widely used to characterize early cerebral metabolic changes associated to aging and AD. (Kalpouzos 2009, Mosconi, 2007). We focused on the small primate (Microce bus murinus (M.m.). During aging some animals develop cognitive impairments (Picq, 2007) amyloid plaque depositions, and altered Tau protein accumulation associated with cerebral atrophy (Kraska, 2009). Brain atrophy is predictive of cognitive alterations (Picq, 2010). The aim of the current study was to evaluate age-associated evolution of glucose uptake in M. m. by using non-invasive FDG PET. Seventeen M.m. (1.5 to 9 years) were evaluated by PET with MicroPET® Focus220 system (FDG: 900uCurie/100g, i.v.) and 3D-MR images were recorded (Pharma Scan Bruker 7T). M.m. were anesthetized by isoflurane during images acquisition. MR and PET images were co-registered by rigid transformations to define volumes of interest (VOI) in brain and appraise Standard Uptake Values (SUV) as well as relative values compared to whole brain. MR images didn't reveal any severe atrophy. This study is focused on normal aging. PET study revealed a relationship between age and SUVs in the frontal cortex, the cerebellum, and in the whole brain. However relative values were not correlated with age. The cohort was split by the M.m. midlife (4.5 years) in two groups, young (1.9 plus or minus 0.2 years) and old animals (6.4 plus or minus 0.5 years). This second analysis showed a difference between young and old animals in the whole brain, frontal cortex, and cerebellum (t-test). An age-associated evolution of glucose uptake as measured by SUVs could be detected in non-severely atrophied M.m. and resembles evolution of the regional cerebral metabolic rates for glucose (rCMRGlc) observed in healthy aged humans. This study is a first step toward the characterization of age-associated changes of brain glucose uptake in M.m. and will be useful to understanding brain aging in M.m." @default.
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• W4251868075 date "2011-07-01" @default.
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• W4251868075 title "P2-002: In-vivo detection of age-related cerebral glucose uptake alterations by pet in microcebus murinus primates" @default.
• W4251868075 doi "https://doi.org/10.1016/j.jalz.2011.05.2437" @default.
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