Matches in SemOpenAlex for { <https://semopenalex.org/work/W4251924530> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W4251924530 endingPage "16" @default.
- W4251924530 startingPage "10" @default.
- W4251924530 abstract "Individual differences in the aging process can be conceptualized as an accumulation of wear and tear of daily experiences and major life stressors that interact with the genetic constitution and predisposing early life experiences. The neuroendocrine system, autonomic nervous system, and immune system are mediators of adaptation to challenges of daily life, referred to as allostasis, meaning “maintaining stability through change.” Physiological mediators such as adrenalin from the adrenal medulla, glucocorticoids from the adrenal cortex, and cytokines from cells of the immune system act upon receptors in various tissues and organs to produce effects that are adaptive in the short run but can be damaging if the mediators are not shut off when no longer needed. When release of the mediators is not efficiently terminated, their effects on target cells are prolonged, leading to other consequences that may include receptor desensitization and tissue damage. This process has been named “allostatic load,” and it refers to the price the tissue or organ pays for an overactive or inefficiently managed allostatic response. Therefore, allostatic load refers to the “cost” of adaptation. This article discusses the mediators of allostasis and their contributions to allostatic load as well as their role in resilience of the aging organism to stressful experiences." @default.
- W4251924530 created "2022-05-12" @default.
- W4251924530 creator A5035103174 @default.
- W4251924530 date "2003-10-01" @default.
- W4251924530 modified "2023-10-18" @default.
- W4251924530 title "Interacting mediators of allostasis and allostatic load: towards an understanding of resilience in aging" @default.
- W4251924530 doi "https://doi.org/10.1053/s0026-0495(03)00295-6" @default.
- W4251924530 hasPublicationYear "2003" @default.
- W4251924530 type Work @default.
- W4251924530 citedByCount "16" @default.
- W4251924530 countsByYear W42519245302012 @default.
- W4251924530 countsByYear W42519245302014 @default.
- W4251924530 countsByYear W42519245302015 @default.
- W4251924530 crossrefType "journal-article" @default.
- W4251924530 hasAuthorship W4251924530A5035103174 @default.
- W4251924530 hasConcept C125370674 @default.
- W4251924530 hasConcept C137176749 @default.
- W4251924530 hasConcept C139807058 @default.
- W4251924530 hasConcept C15744967 @default.
- W4251924530 hasConcept C157541749 @default.
- W4251924530 hasConcept C169760540 @default.
- W4251924530 hasConcept C187150481 @default.
- W4251924530 hasConcept C2778654844 @default.
- W4251924530 hasConcept C77805123 @default.
- W4251924530 hasConceptScore W4251924530C125370674 @default.
- W4251924530 hasConceptScore W4251924530C137176749 @default.
- W4251924530 hasConceptScore W4251924530C139807058 @default.
- W4251924530 hasConceptScore W4251924530C15744967 @default.
- W4251924530 hasConceptScore W4251924530C157541749 @default.
- W4251924530 hasConceptScore W4251924530C169760540 @default.
- W4251924530 hasConceptScore W4251924530C187150481 @default.
- W4251924530 hasConceptScore W4251924530C2778654844 @default.
- W4251924530 hasConceptScore W4251924530C77805123 @default.
- W4251924530 hasLocation W42519245301 @default.
- W4251924530 hasOpenAccess W4251924530 @default.
- W4251924530 hasPrimaryLocation W42519245301 @default.
- W4251924530 hasRelatedWork W2074123474 @default.
- W4251924530 hasRelatedWork W2119864857 @default.
- W4251924530 hasRelatedWork W2150561902 @default.
- W4251924530 hasRelatedWork W2331661004 @default.
- W4251924530 hasRelatedWork W2785402381 @default.
- W4251924530 hasRelatedWork W2902922072 @default.
- W4251924530 hasRelatedWork W2920891356 @default.
- W4251924530 hasRelatedWork W3199157127 @default.
- W4251924530 hasRelatedWork W332112469 @default.
- W4251924530 hasRelatedWork W4200075766 @default.
- W4251924530 hasVolume "52" @default.
- W4251924530 isParatext "false" @default.
- W4251924530 isRetracted "false" @default.
- W4251924530 workType "article" @default.