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- W4252003018 abstract "Integrins α4 are required for postnatal lymphopoiesis in the bone marrow. They are also necessary for lymphocyte homing to Peyer's patches. Integrin α4 complexes with two different integrin β subunits. α4β1 and α4β7 are receptors for both an alternatively spliced form of fibronectin and for the Ig superfamily molecule VCAM-1. This chapter presents a study in which homozygotes showed embryonic lethality. Approximately half the embryos failed to form a placenta because of failure of fusion between the allantois and the chorion. The rest died by cardiac hemorrhage resulting from detachment and rupture of the epicardium and the coronary vessels which lied below it. Integrins α4 appear to be dispensible for myogenesis or muscle development." @default.
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- W4252003018 date "1998-01-01" @default.
- W4252003018 modified "2023-09-27" @default.
- W4252003018 title "Integrin α4" @default.
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- W4252003018 doi "https://doi.org/10.1016/b978-012466044-1/50345-8" @default.
- W4252003018 hasPublicationYear "1998" @default.
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