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- W4252006871 abstract "A comparison has been made between four 6-month daily regimens, all containing streptomycin plus isoniazid, and three of them a third drug—rifampicin, pyrazinamide, or thiacetazone—and a standard 18-month regimen in the treatment of newly diagnosed extensive smear-positive pulmonary tuberculosis. At 6 months only 4 of 860 patients (1 on streptomycin plus isoniazid, 3 on the standard regimen) were clearcut failures of chemotherapy. There was also very little drug toxicity. The bacteriological relapse-rates between 6 and 18 months were 27% of 114 patients on the two-drug combination, 2% of 119 on the rifampicin, 10% of 124 on the pyrazinamide, 22% of 102 on the thiacetazone, and 3% of 109 patients on the standard regimen. In a larger comparison of the three most effective regimens the relapse-rates were 3% of 156 rifampicin patients, 8% of 167 pyrazinamide, and 2% of 139 standard regimen patients. Most of the relapses occurred by 12 months, and nearly every patient who relapsed did so with drug-sensitive organisms. It is concluded that the rifampicin regimen was highly effective, despite the severity of the disease under treatment, and that the pyrazinamide regimen approached it in efficacy, comparing favourably with the standard regimen." @default.
- W4252006871 created "2022-05-12" @default.
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- W4252006871 date "1973-06-01" @default.
- W4252006871 modified "2023-09-26" @default.
- W4252006871 title "CONTROLLED CLINICAL TRIAL OF FOUR SHORT-COURSE (6-MONTH) REGIMENS OF CHEMOTHERAPY FOR TREATMENT OF PULMONARY TUBERCULOSIS Second Report" @default.
- W4252006871 doi "https://doi.org/10.1016/s0140-6736(73)91671-1" @default.
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