Matches in SemOpenAlex for { <https://semopenalex.org/work/W4252063544> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4252063544 abstract "Targeting rexinoid X receptor (RXR) has been proposed as one of the therapeutic strategies to treat individuals with metabolic syndrome, because RXR heterodimerizes with multiple nuclear receptors that regulate genes involved in metabolism. Despite numerous efforts, RXR ligands (rexinoids) have not been approved for clinical trials to treat metabolic syndrome due to the serious side effects such as hypertriglyceridemia and altered thyroid hormone axis. Herein, we demonstrate a novel rexinoid-like small molecule, UAB126, which has positive effects on metabolic syndrome without the known side effects of potent rexinoids. Oral administration of UAB126 ameliorated obesity, insulin resistance, hepatic steatosis, and hyperlipidemia without changes in food intake, physical activity, and thyroid hormone levels. RNA-seq analysis revealed that UAB126 regulates the expression of genes in the liver that are modulated by several nuclear receptors, including peroxisome proliferator-activated receptor (PPAR) alpha and/or liver X receptor (LXR) in conjunction with retinoid X receptor (RXR). Furthermore, UAB126 not only prevented but also reversed obesity-associated metabolic disorders. The results suggest that optimized modulation of RXR may be a promising strategy to treat metabolic disorders without side effects. Thus, the present study reveals that UAB126 offers as an attractive therapy to treat individuals with obesity and its co-morbidities." @default.
- W4252063544 created "2022-05-12" @default.
- W4252063544 creator A5001683412 @default.
- W4252063544 creator A5001920865 @default.
- W4252063544 creator A5002361220 @default.
- W4252063544 creator A5009005963 @default.
- W4252063544 creator A5009269808 @default.
- W4252063544 creator A5009647225 @default.
- W4252063544 creator A5012101863 @default.
- W4252063544 creator A5017941789 @default.
- W4252063544 creator A5023858699 @default.
- W4252063544 creator A5026708404 @default.
- W4252063544 creator A5034766267 @default.
- W4252063544 creator A5051474316 @default.
- W4252063544 creator A5052123970 @default.
- W4252063544 creator A5068390739 @default.
- W4252063544 creator A5073001632 @default.
- W4252063544 creator A5091066153 @default.
- W4252063544 date "2020-07-08" @default.
- W4252063544 modified "2023-09-27" @default.
- W4252063544 title "A Small Molecule, UAB126, Reverses Diet-Induced Obesity and Its Associated Metabolic Disorders" @default.
- W4252063544 doi "https://doi.org/10.2337/figshare.12505421" @default.
- W4252063544 hasPublicationYear "2020" @default.
- W4252063544 type Work @default.
- W4252063544 citedByCount "0" @default.
- W4252063544 crossrefType "posted-content" @default.
- W4252063544 hasAuthorship W4252063544A5001683412 @default.
- W4252063544 hasAuthorship W4252063544A5001920865 @default.
- W4252063544 hasAuthorship W4252063544A5002361220 @default.
- W4252063544 hasAuthorship W4252063544A5009005963 @default.
- W4252063544 hasAuthorship W4252063544A5009269808 @default.
- W4252063544 hasAuthorship W4252063544A5009647225 @default.
- W4252063544 hasAuthorship W4252063544A5012101863 @default.
- W4252063544 hasAuthorship W4252063544A5017941789 @default.
- W4252063544 hasAuthorship W4252063544A5023858699 @default.
- W4252063544 hasAuthorship W4252063544A5026708404 @default.
- W4252063544 hasAuthorship W4252063544A5034766267 @default.
- W4252063544 hasAuthorship W4252063544A5051474316 @default.
- W4252063544 hasAuthorship W4252063544A5052123970 @default.
- W4252063544 hasAuthorship W4252063544A5068390739 @default.
- W4252063544 hasAuthorship W4252063544A5073001632 @default.
- W4252063544 hasAuthorship W4252063544A5091066153 @default.
- W4252063544 hasBestOaLocation W42520635441 @default.
- W4252063544 hasConcept C104317684 @default.
- W4252063544 hasConcept C109115496 @default.
- W4252063544 hasConcept C126322002 @default.
- W4252063544 hasConcept C128821507 @default.
- W4252063544 hasConcept C134018914 @default.
- W4252063544 hasConcept C167400880 @default.
- W4252063544 hasConcept C170493617 @default.
- W4252063544 hasConcept C187345961 @default.
- W4252063544 hasConcept C2776919658 @default.
- W4252063544 hasConcept C2778163477 @default.
- W4252063544 hasConcept C2778913445 @default.
- W4252063544 hasConcept C2780578515 @default.
- W4252063544 hasConcept C511355011 @default.
- W4252063544 hasConcept C55493867 @default.
- W4252063544 hasConcept C63932345 @default.
- W4252063544 hasConcept C68484354 @default.
- W4252063544 hasConcept C71315377 @default.
- W4252063544 hasConcept C71924100 @default.
- W4252063544 hasConcept C86339819 @default.
- W4252063544 hasConcept C86803240 @default.
- W4252063544 hasConceptScore W4252063544C104317684 @default.
- W4252063544 hasConceptScore W4252063544C109115496 @default.
- W4252063544 hasConceptScore W4252063544C126322002 @default.
- W4252063544 hasConceptScore W4252063544C128821507 @default.
- W4252063544 hasConceptScore W4252063544C134018914 @default.
- W4252063544 hasConceptScore W4252063544C167400880 @default.
- W4252063544 hasConceptScore W4252063544C170493617 @default.
- W4252063544 hasConceptScore W4252063544C187345961 @default.
- W4252063544 hasConceptScore W4252063544C2776919658 @default.
- W4252063544 hasConceptScore W4252063544C2778163477 @default.
- W4252063544 hasConceptScore W4252063544C2778913445 @default.
- W4252063544 hasConceptScore W4252063544C2780578515 @default.
- W4252063544 hasConceptScore W4252063544C511355011 @default.
- W4252063544 hasConceptScore W4252063544C55493867 @default.
- W4252063544 hasConceptScore W4252063544C63932345 @default.
- W4252063544 hasConceptScore W4252063544C68484354 @default.
- W4252063544 hasConceptScore W4252063544C71315377 @default.
- W4252063544 hasConceptScore W4252063544C71924100 @default.
- W4252063544 hasConceptScore W4252063544C86339819 @default.
- W4252063544 hasConceptScore W4252063544C86803240 @default.
- W4252063544 hasLocation W42520635441 @default.
- W4252063544 hasLocation W42520635442 @default.
- W4252063544 hasOpenAccess W4252063544 @default.
- W4252063544 hasPrimaryLocation W42520635441 @default.
- W4252063544 hasRelatedWork W10268724 @default.
- W4252063544 hasRelatedWork W2676759 @default.
- W4252063544 hasRelatedWork W3009035 @default.
- W4252063544 hasRelatedWork W4025577 @default.
- W4252063544 hasRelatedWork W4571987 @default.
- W4252063544 hasRelatedWork W4980172 @default.
- W4252063544 hasRelatedWork W5157238 @default.
- W4252063544 hasRelatedWork W6030011 @default.
- W4252063544 hasRelatedWork W8766565 @default.
- W4252063544 hasRelatedWork W1782945 @default.
- W4252063544 isParatext "false" @default.
- W4252063544 isRetracted "false" @default.
- W4252063544 workType "article" @default.