Matches in SemOpenAlex for { <https://semopenalex.org/work/W4252088897> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4252088897 endingPage "737" @default.
- W4252088897 startingPage "731" @default.
- W4252088897 abstract "Many synthetic peptide-based prolyl endopeptidase (PEP) inhibitors are depended on the acy-l-L-prolyl-pyrrolidine structure. The pyrrolidine ring at P1 and a large variety of lipophilic acyl groups at P3 have been reported to be important for potent PEP inhibitory activity. Upon exploration of a new lead compound for PEP inhibition, succinic acid was introduced at the P2 position to replace the l-proline in acyl-l-prolyl-pyrrolidine. A series of amido-succinylpyrrolidine compounds (1–9) were synthesized, and their PEP inhibitory activities were evaluated. Of these, compound 9 showed the most potent PEP inhibitory activity with IC50 of 6.4±0.6 nM." @default.
- W4252088897 created "2022-05-12" @default.
- W4252088897 creator A5049542528 @default.
- W4252088897 date "2011-10-31" @default.
- W4252088897 modified "2023-10-01" @default.
- W4252088897 title "Synthesis and Evaluation of Succinic Acid Derivatives as Prolyl Endopeptidase Inhibitors" @default.
- W4252088897 doi "https://doi.org/10.3839/jksabc.2011.110" @default.
- W4252088897 hasPublicationYear "2011" @default.
- W4252088897 type Work @default.
- W4252088897 citedByCount "0" @default.
- W4252088897 crossrefType "journal-article" @default.
- W4252088897 hasAuthorship W4252088897A5049542528 @default.
- W4252088897 hasBestOaLocation W42520888971 @default.
- W4252088897 hasConcept C169760540 @default.
- W4252088897 hasConcept C17077164 @default.
- W4252088897 hasConcept C178790620 @default.
- W4252088897 hasConcept C181199279 @default.
- W4252088897 hasConcept C185592680 @default.
- W4252088897 hasConcept C202751555 @default.
- W4252088897 hasConcept C2776775109 @default.
- W4252088897 hasConcept C2777735259 @default.
- W4252088897 hasConcept C2777752497 @default.
- W4252088897 hasConcept C2778851528 @default.
- W4252088897 hasConcept C2779281246 @default.
- W4252088897 hasConcept C2779815552 @default.
- W4252088897 hasConcept C2780378348 @default.
- W4252088897 hasConcept C2781041046 @default.
- W4252088897 hasConcept C515207424 @default.
- W4252088897 hasConcept C55493867 @default.
- W4252088897 hasConcept C71240020 @default.
- W4252088897 hasConcept C86803240 @default.
- W4252088897 hasConceptScore W4252088897C169760540 @default.
- W4252088897 hasConceptScore W4252088897C17077164 @default.
- W4252088897 hasConceptScore W4252088897C178790620 @default.
- W4252088897 hasConceptScore W4252088897C181199279 @default.
- W4252088897 hasConceptScore W4252088897C185592680 @default.
- W4252088897 hasConceptScore W4252088897C202751555 @default.
- W4252088897 hasConceptScore W4252088897C2776775109 @default.
- W4252088897 hasConceptScore W4252088897C2777735259 @default.
- W4252088897 hasConceptScore W4252088897C2777752497 @default.
- W4252088897 hasConceptScore W4252088897C2778851528 @default.
- W4252088897 hasConceptScore W4252088897C2779281246 @default.
- W4252088897 hasConceptScore W4252088897C2779815552 @default.
- W4252088897 hasConceptScore W4252088897C2780378348 @default.
- W4252088897 hasConceptScore W4252088897C2781041046 @default.
- W4252088897 hasConceptScore W4252088897C515207424 @default.
- W4252088897 hasConceptScore W4252088897C55493867 @default.
- W4252088897 hasConceptScore W4252088897C71240020 @default.
- W4252088897 hasConceptScore W4252088897C86803240 @default.
- W4252088897 hasIssue "5" @default.
- W4252088897 hasLocation W42520888971 @default.
- W4252088897 hasOpenAccess W4252088897 @default.
- W4252088897 hasPrimaryLocation W42520888971 @default.
- W4252088897 hasRelatedWork W1982135023 @default.
- W4252088897 hasRelatedWork W2021131778 @default.
- W4252088897 hasRelatedWork W2036798434 @default.
- W4252088897 hasRelatedWork W2215143303 @default.
- W4252088897 hasRelatedWork W2330961599 @default.
- W4252088897 hasRelatedWork W2949330193 @default.
- W4252088897 hasRelatedWork W2949754589 @default.
- W4252088897 hasRelatedWork W3158115993 @default.
- W4252088897 hasRelatedWork W4252062796 @default.
- W4252088897 hasRelatedWork W4252088897 @default.
- W4252088897 hasVolume "54" @default.
- W4252088897 isParatext "false" @default.
- W4252088897 isRetracted "false" @default.
- W4252088897 workType "article" @default.