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- W4252116798 abstract "During the process of cell division, if chromosomes fail to align correctly on the bipolar mitotic spindle, completion of mitosis will be delayed until alignment has been corrected. Martin-Lluesma et al. describe the role of a protein, Hec1, that recruits a pair of proteins, Mad1 and Mad 2, to the kinetochores at the center of condensed chromosomes. This interaction is important both for the binding of kinetochores to the microtubules of the mitotic spindle and for maintenance of the spindle checkpoint. Mad 1 and Mad 2 were already known to be involved in the spindle checkpoint, but the contribution of Hec1 had been unanticipated and suggests an additional degree of complexity in checkpoint controls in higher eukaryotes versus yeast.S. Martin-Lluesma, V. M. Stucke, E. A. Nigg, Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science 297, 2267-2270 (2002). [Abstract] [Full Text]" @default.
- W4252116798 created "2022-05-12" @default.
- W4252116798 date "2002-10-01" @default.
- W4252116798 modified "2023-10-18" @default.
- W4252116798 title "Checking the Spindle" @default.
- W4252116798 doi "https://doi.org/10.1126/stke.2002.152.tw359" @default.
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