Matches in SemOpenAlex for { <https://semopenalex.org/work/W4252132035> ?p ?o ?g. }
- W4252132035 endingPage "462" @default.
- W4252132035 startingPage "454" @default.
- W4252132035 abstract "Three cerium complexes: [Ce(ClQ)4] (1) (H-ClQ = 5,7-dichloro-8-hydroxylquinoline), [Ce(ClIQ)4]·CH2Cl2·0.5H2O (2) (H-ClIQ = 5-chloro-7-iodo-8-hydroxylquinoline) and [Ce2(BrQ)4(H-BrQ)(H2O)3Cl2]·1.5H2O (3) (H-BrQ = 5,7-dibromo-8-hydroxylquinoline) were synthesized. The structures of 1 and 2 are mononuclear whereas 3 has a binuclear structure. Compared with the H-ClQ, H-ClIQ and H-BrQ, complexes 1–3 exhibited significantly higher cytotoxicity (IC50 = 0.09–5.23 μM) to SK-OV-3 and BEL-7404, 1 and 2 exhibited higher cytotoxicity to NCI-H460. Most the complexes and ligands exhibited higher cytotoxicity than cisplatin. Complexes 1–3 are much more sensitive to SK-OV-3 than to human normal liver cell HL-7702. Their antitumor activities were achieved through cell apoptosis and arrest at G0/G1-phase. Studies on the binding properties of 1–3 to DNA indicate that intercalation is the most probable binding mode." @default.
- W4252132035 created "2022-05-12" @default.
- W4252132035 creator A5016171867 @default.
- W4252132035 creator A5019112889 @default.
- W4252132035 creator A5026510579 @default.
- W4252132035 creator A5028680576 @default.
- W4252132035 creator A5036726873 @default.
- W4252132035 creator A5045123174 @default.
- W4252132035 creator A5066517933 @default.
- W4252132035 creator A5068149448 @default.
- W4252132035 date "2013-10-01" @default.
- W4252132035 modified "2023-10-17" @default.
- W4252132035 title "High antitumor activity of 5,7-dihalo-8-quinolinolato cerium complexes" @default.
- W4252132035 cites W1986406178 @default.
- W4252132035 cites W1989440050 @default.
- W4252132035 cites W1993582814 @default.
- W4252132035 cites W1995416061 @default.
- W4252132035 cites W1999798503 @default.
- W4252132035 cites W2001976945 @default.
- W4252132035 cites W2012277863 @default.
- W4252132035 cites W2014516746 @default.
- W4252132035 cites W2025940819 @default.
- W4252132035 cites W2030501049 @default.
- W4252132035 cites W2031713883 @default.
- W4252132035 cites W2037624547 @default.
- W4252132035 cites W2040859691 @default.
- W4252132035 cites W2041689008 @default.
- W4252132035 cites W2046773644 @default.
- W4252132035 cites W2054902044 @default.
- W4252132035 cites W2055263756 @default.
- W4252132035 cites W2059972850 @default.
- W4252132035 cites W2068234076 @default.
- W4252132035 cites W2070034593 @default.
- W4252132035 cites W2073057404 @default.
- W4252132035 cites W2073772474 @default.
- W4252132035 cites W2077140040 @default.
- W4252132035 cites W2078440422 @default.
- W4252132035 cites W2099362727 @default.
- W4252132035 cites W2104443668 @default.
- W4252132035 cites W2105058945 @default.
- W4252132035 cites W2113969097 @default.
- W4252132035 cites W2133927824 @default.
- W4252132035 cites W2148968934 @default.
- W4252132035 cites W2155204101 @default.
- W4252132035 cites W2155335795 @default.
- W4252132035 cites W2165810890 @default.
- W4252132035 cites W2327659954 @default.
- W4252132035 cites W4240491556 @default.
- W4252132035 doi "https://doi.org/10.1016/j.ejmech.2013.08.007" @default.
- W4252132035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23995094" @default.
- W4252132035 hasPublicationYear "2013" @default.
- W4252132035 type Work @default.
- W4252132035 citedByCount "39" @default.
- W4252132035 countsByYear W42521320352014 @default.
- W4252132035 countsByYear W42521320352015 @default.
- W4252132035 countsByYear W42521320352016 @default.
- W4252132035 countsByYear W42521320352017 @default.
- W4252132035 countsByYear W42521320352018 @default.
- W4252132035 countsByYear W42521320352019 @default.
- W4252132035 countsByYear W42521320352020 @default.
- W4252132035 countsByYear W42521320352021 @default.
- W4252132035 countsByYear W42521320352022 @default.
- W4252132035 countsByYear W42521320352023 @default.
- W4252132035 crossrefType "journal-article" @default.
- W4252132035 hasAuthorship W4252132035A5016171867 @default.
- W4252132035 hasAuthorship W4252132035A5019112889 @default.
- W4252132035 hasAuthorship W4252132035A5026510579 @default.
- W4252132035 hasAuthorship W4252132035A5028680576 @default.
- W4252132035 hasAuthorship W4252132035A5036726873 @default.
- W4252132035 hasAuthorship W4252132035A5045123174 @default.
- W4252132035 hasAuthorship W4252132035A5066517933 @default.
- W4252132035 hasAuthorship W4252132035A5068149448 @default.
- W4252132035 hasConcept C109316439 @default.
- W4252132035 hasConcept C137061746 @default.
- W4252132035 hasConcept C137824038 @default.
- W4252132035 hasConcept C155647269 @default.
- W4252132035 hasConcept C178790620 @default.
- W4252132035 hasConcept C185592680 @default.
- W4252132035 hasConcept C190283241 @default.
- W4252132035 hasConcept C202751555 @default.
- W4252132035 hasConcept C523597863 @default.
- W4252132035 hasConcept C552990157 @default.
- W4252132035 hasConcept C55493867 @default.
- W4252132035 hasConcept C71240020 @default.
- W4252132035 hasConceptScore W4252132035C109316439 @default.
- W4252132035 hasConceptScore W4252132035C137061746 @default.
- W4252132035 hasConceptScore W4252132035C137824038 @default.
- W4252132035 hasConceptScore W4252132035C155647269 @default.
- W4252132035 hasConceptScore W4252132035C178790620 @default.
- W4252132035 hasConceptScore W4252132035C185592680 @default.
- W4252132035 hasConceptScore W4252132035C190283241 @default.
- W4252132035 hasConceptScore W4252132035C202751555 @default.
- W4252132035 hasConceptScore W4252132035C523597863 @default.
- W4252132035 hasConceptScore W4252132035C552990157 @default.
- W4252132035 hasConceptScore W4252132035C55493867 @default.
- W4252132035 hasConceptScore W4252132035C71240020 @default.
- W4252132035 hasFunder F4320321001 @default.
- W4252132035 hasFunder F4320322768 @default.