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- W4252133715 abstract "Abstract Ying Wang-Tilz, Christian Tilz, Bing Wang, Gernot P. Tilz, and Hermann Stefan Some individuals with epilepsy appear resistant to most or all antiepileptic medications. One possible explanation for this resistance is the presence of a gene called MDR1 that causes production in the brain of a substance called p-glycoprotein (P-gp). We studied a model of epilepsy in rats produced by repeated injections of Coriaria lactone, an epileptogenic plant toxin. The clinical antiepileptic drugs, topiramate and lamotrigine, significantly reduced seizures. With these two drugs, P-gp was not increased in brain. In contrast, carbamazepine and valproate did increase brain P-gp, and these drugs were less beneficial against the seizures. These results suggest that attention could usefully be paid to whether medications activate multiple drug-resistance genes in brain, because such an effect could counteract the effectiveness of a medication." @default.
- W4252133715 created "2022-05-12" @default.
- W4252133715 date "2006-02-01" @default.
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- W4252133715 title "Basic Science" @default.
- W4252133715 doi "https://doi.org/10.1111/j.1528-1167.2006.00413_1.x" @default.
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