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- W4252185514 abstract "Prion diseases from a spectrum of disorders in animals and man characterized by a change in the secondary structure of the prion protein. Variant Creutzfeldt-Jakob disease has been shown to be transmissible by transfusion of many different blood components in animal models and by red cell transfusion in man. Many uncertainties as to the nature and size of the risk still pertain including the prevalence of subclinical infection in donor populations, the levels and distribution of infectivity in peripheral blood and the susceptibility of individuals to the development of neurological disease. Whilst a number of precautionary risk mitigation measures have been put in place by Blood Services, the potential utility of further measures such as prion filtration or blood donor screening remains a matter of debate. The scientific, medical and ethical challenges involved in managing this risk remain substantial." @default.
- W4252185514 created "2022-05-12" @default.
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- W4252185514 date "2016-04-15" @default.
- W4252185514 modified "2023-10-17" @default.
- W4252185514 title "Prion diseases" @default.
- W4252185514 doi "https://doi.org/10.1002/9781119013020.ch54" @default.
- W4252185514 hasPublicationYear "2016" @default.
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