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- W4252188214 abstract "Abstract Background: Recent evidence indicates that disrupted sleep could contribute to the development of Alzheimer’s disease by influencing the production and/or clearance of the amyloid-β protein. We set up a case-control study to investigated the association between long-term work-induced sleep disruption, cognitive function, and brain amyloid-β accumulation.Methods: We recruited 19 male maritime pilots (aged 48-60 years) with chronic work-related sleep disruption and a sex-, age and education-matched control sample (n=16, aged 50-60 years) with normal sleep. Primary sleep disorders were ruled out with in-lab polysomnography. Additional sleep measurements were obtained at home using actigraphy, sleep-wake logs, and a single-lead EEG device. Cognitive function was assessed with a neuropsychological test battery sensitive to early symptomatic Alzheimer’s disease. Brain amyloid-β accumulation was assessed in maritime pilots using 18 F-flutemetamol amyloid PET-CT.Results: Maritime pilots reported significantly worse sleep quality (Pittsburgh Sleep Quality Index (PSQI)=8.8±2.9) during workweeks, compared to controls (PSQI=3.2±1.4; 95% CI 0.01 to 2.57; p =0.049). This was confirmed with actigraphy-based sleep efficiency (86% ±3.8 vs. 89.3% ±4.3; 95% CI 0.43 to 6.03; p =0.03). Home-EEG recordings showed less total sleep time and deep sleep time during workweeks compared to rest-weeks (TST: 318.56 (250.21–352.93) vs. TST: 406.17 (340–425.98); p =0.001; DST: 36.75 (32.30–58.58) vs. DST 51.34 (48.37–69.30); p =0.005)). There were no differences in any of the cognitive domains between the groups. Abnormal amyloid-β accumulation was ruled out, showing mean global cortical standard uptake value ratios in the normal range (1.009 ±0.059; 95% CI 0.980 to 1.037), confirmed by visual reads.Conclusions: Capitalizing on the particular work-rest schedule of maritime pilots, we show that long-term intermittent sleep disruption is not associated with brain amyloid accumulation or cognitive decline." @default.
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- W4252188214 date "2020-04-28" @default.
- W4252188214 modified "2023-10-16" @default.
- W4252188214 title "Effect of long-term sleep disruption on cognitive function and brain amyloid-β accumulation: a case-control study" @default.
- W4252188214 doi "https://doi.org/10.21203/rs.3.rs-24688/v1" @default.
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