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- W4252342853 abstract "OBJECTIVE The long-term results of transsphenoidal surgery for microprolactinoma, with particular reference to the question of permanence of relapse of hyperprolactinemia after biochemical cure, are examined. METHODS Patients whose operations were performed in the city of Glasgow, Scotland, by one neurosurgeon (GMT) have been followed up for between 15 and 21 years after surgery was performed. RESULTS Of a cohort of 44 patients with confirmed microprolactinoma at the time of surgery, 8 patients (18.2%) who experienced recurrent hyperprolactinemia postoperatively continued to be monitored. Selective hypophysectomy resulted in normal prolactin levels in all patients initially. Relapse occurred at 2 to 10 years (mean, 5.3 yr) postoperatively, but was permanent in only two patients (4.5%). Of the remaining six patients (13.6%), four (9.1%) became normoprolactinemic after 6 or 7 years’ recurrence, and two (4.5%) are now only marginally hyperprolactinemic (prolactin >500 but <700 mU/L) at 15 and 18 years after transsphenoidal hypophysectomy. CONCLUSION The recurrence of hyperprolactinemia after transsphenoidal surgery for microprolactinoma is not necessarily a permanent feature and does not inevitably indicate operative failure." @default.
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- W4252342853 date "2002-01-01" @default.
- W4252342853 modified "2023-09-26" @default.
- W4252342853 title "Relapse of Hyperprolactinemia after Transsphenoidal Surgery for Microprolactinoma: Lessons from Long-term Follow-up" @default.
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- W4252342853 doi "https://doi.org/10.1227/00006123-200201000-00007" @default.
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