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- W4252401126 endingPage "3447" @default.
- W4252401126 startingPage "3439" @default.
- W4252401126 abstract "Hodgkin lymphoma (HL), a B cell-derived cancer, is one of the most common lymphomas. In HL, the tumor cells--Hodgkin and Reed-Sternberg (HRS) cells--are usually very rare in the tissue. Although HRS cells are derived from mature B cells, they have largely lost their B cell phenotype and show a very unusual co-expression of markers of various hematopoietic cell types. HRS cells show deregulated activation of multiple signaling pathways and transcription factors. The activation of these pathways and factors is partly mediated through interactions of HRS cells with various other types of cells in the microenvironment, but also through genetic lesions. The transforming events involved in the pathogenesis of HL are only partly understood, but mutations affecting the NF-κB and JAK/STAT pathways are frequent. The dependency of HRS cells on microenvironmental interactions and deregulated signaling pathways may offer novel strategies for targeted therapies." @default.
- W4252401126 created "2022-05-12" @default.
- W4252401126 creator A5018156469 @default.
- W4252401126 creator A5057387418 @default.
- W4252401126 creator A5091333429 @default.
- W4252401126 date "2012-10-01" @default.
- W4252401126 modified "2023-10-16" @default.
- W4252401126 title "Hodgkin lymphoma" @default.
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