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- W4252402917 abstract "Prevailing immunological dogma dictates self-nonself discrimination, meaning to respond or not, and effector class regulation, meaning choosing the most effective response, are two separate decisions the immune system makes when faced with a new antigen. Representing a cardinal departure from the past, our model instead predicts both self-nonself discrimination and effector class regulation are in fact one and the same process controlled by Foxp3 + regulatory T cells (Tregs) whose antigen-specific repertoire is entirely maintained by commensal microbiota-derived cross-reactive antigens." @default.
- W4252402917 created "2022-05-12" @default.
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- W4252402917 date "2017-07-10" @default.
- W4252402917 modified "2023-10-16" @default.
- W4252402917 title "An identical mechanism governs self-nonself discrimination and effector class regulation" @default.
- W4252402917 doi "https://doi.org/10.7287/peerj.preprints.3081" @default.
- W4252402917 hasPublicationYear "2017" @default.
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