Matches in SemOpenAlex for { <https://semopenalex.org/work/W4252462956> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4252462956 abstract "The influences of water activity and solvent hydrophobicity on the kinetics of the lipase-catalyzed enantioselective esterification of flurbiprofen with n-butanol were investigated. The solvent effect was not similar for lipases from Candida rugosa (Crl), Mucor javanicus (Mjl), and porcine pancreas (Ppl). The lipase-catalyzed reaction rates in different solvents across a wide range of water activities revealed that the Ppl-catalyzed reaction exhibited no enantioselectivity and no substantial water activity or solvent dependence. The Mjl-catalyzed reaction proceeded faster, preferring the R-enantiomer reaction over that of its antipode, but had little solvent or water activity dependence. The Crl-catalyzed reactions in n-heptane and n-nonane had similar water activity dependence, but the reaction was considerably faster and more enantioselective (preferring the S-enantiomer reaction) in isooctane, a solvent whose hydrophobicity is intermediate between that of the other two alkanes. Substrate enantiomeric excess, for the Crl-catalyzed reaction at 96 hours and at a water activity of 0.65, in n-heptane, isooctane, and n-nonane was 40.9, 93.0, and 50.0%, respectively. Since the three solvents possess similar physical properties, the explanation for this anomalous behavior might be the effect of the solvent structural characteristics on Crl, since isooctane is the only branched alkane." @default.
- W4252462956 created "2022-05-12" @default.
- W4252462956 creator A5078129340 @default.
- W4252462956 creator A5082879794 @default.
- W4252462956 date "2000-12-15" @default.
- W4252462956 modified "2023-10-05" @default.
- W4252462956 title "Lipase-catalyzed enantioselective esterification of flurbiprofen with n-butanol" @default.
- W4252462956 doi "https://doi.org/10.2225/vol3-issue3-fulltext-3" @default.
- W4252462956 hasPublicationYear "2000" @default.
- W4252462956 type Work @default.
- W4252462956 citedByCount "1" @default.
- W4252462956 countsByYear W42524629562015 @default.
- W4252462956 crossrefType "journal-article" @default.
- W4252462956 hasAuthorship W4252462956A5078129340 @default.
- W4252462956 hasAuthorship W4252462956A5082879794 @default.
- W4252462956 hasBestOaLocation W42524629561 @default.
- W4252462956 hasConcept C146686406 @default.
- W4252462956 hasConcept C161790260 @default.
- W4252462956 hasConcept C178790620 @default.
- W4252462956 hasConcept C181199279 @default.
- W4252462956 hasConcept C185592680 @default.
- W4252462956 hasConcept C2777713963 @default.
- W4252462956 hasConcept C2779697368 @default.
- W4252462956 hasConcept C2780161600 @default.
- W4252462956 hasConcept C2780786110 @default.
- W4252462956 hasConcept C2781000538 @default.
- W4252462956 hasConcept C55493867 @default.
- W4252462956 hasConcept C86803240 @default.
- W4252462956 hasConcept C98274493 @default.
- W4252462956 hasConceptScore W4252462956C146686406 @default.
- W4252462956 hasConceptScore W4252462956C161790260 @default.
- W4252462956 hasConceptScore W4252462956C178790620 @default.
- W4252462956 hasConceptScore W4252462956C181199279 @default.
- W4252462956 hasConceptScore W4252462956C185592680 @default.
- W4252462956 hasConceptScore W4252462956C2777713963 @default.
- W4252462956 hasConceptScore W4252462956C2779697368 @default.
- W4252462956 hasConceptScore W4252462956C2780161600 @default.
- W4252462956 hasConceptScore W4252462956C2780786110 @default.
- W4252462956 hasConceptScore W4252462956C2781000538 @default.
- W4252462956 hasConceptScore W4252462956C55493867 @default.
- W4252462956 hasConceptScore W4252462956C86803240 @default.
- W4252462956 hasConceptScore W4252462956C98274493 @default.
- W4252462956 hasIssue "3" @default.
- W4252462956 hasLocation W42524629561 @default.
- W4252462956 hasLocation W42524629562 @default.
- W4252462956 hasLocation W42524629563 @default.
- W4252462956 hasLocation W42524629564 @default.
- W4252462956 hasOpenAccess W4252462956 @default.
- W4252462956 hasPrimaryLocation W42524629561 @default.
- W4252462956 hasRelatedWork W1966403397 @default.
- W4252462956 hasRelatedWork W1989774978 @default.
- W4252462956 hasRelatedWork W2019152678 @default.
- W4252462956 hasRelatedWork W2060559112 @default.
- W4252462956 hasRelatedWork W2069823711 @default.
- W4252462956 hasRelatedWork W209391081 @default.
- W4252462956 hasRelatedWork W2326320158 @default.
- W4252462956 hasRelatedWork W2373732152 @default.
- W4252462956 hasRelatedWork W2474798303 @default.
- W4252462956 hasRelatedWork W2950773651 @default.
- W4252462956 hasVolume "3" @default.
- W4252462956 isParatext "false" @default.
- W4252462956 isRetracted "false" @default.
- W4252462956 workType "article" @default.