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- W4252476223 abstract "Zonisamide was licensed as add-on therapy for focal seizures in adults in the USA in 2000 and in the EU in 2005. Zonisamide is effective in several experimental models of seizures and epilepsy. A mechanism of action similar to that of phenytoin is suggested by its activity against maximum electroshock (MES) seizures and its ability to inhibit sustained repetitive action potential firing in cultured spinal cord neurons at clinically relevant concentrations. Information on the pharmacokinetics of zonisamide in special groups is limited. Zonisamide has no clinically relevant effects on the pharmacokinetics of other commonly used AEDs. Although serum zonisamide concentrations can be measured by enzyme-linked immunoassay or high-performance liquid chromatography, the relationship between serum concentrations and efficacy is not sufficiently characterized to recommend extensive monitoring in routine clinical practice. It is an antiepileptic drug, which can be useful for the mono- and adjunctive therapy of focal epilepsies." @default.
- W4252476223 created "2022-05-12" @default.
- W4252476223 date "2015-10-02" @default.
- W4252476223 modified "2023-09-25" @default.
- W4252476223 title "Zonisamide" @default.
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