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- W4252554796 abstract "<b>Objective:</b> <p>Developing country-specific unit-cost catalogs is a key area for advancing economic research to improve medical and policy decisions. However, little is known about how healthcare costs vary by type 2 diabetes (T2D) complications across time in Asian countries. We sought to quantify the economic burden of various T2D complications in Taiwan.</p> <p> </p> <p><b>Research Design and Methods:</b></p> <p>A nationwide population-based, longitudinal study was conducted to analyze 802,429 adults with newly-diagnosed T2D identified during 1999-2010 and followed-up until death or December 31, 2013.<b> </b>Annual healthcare costs associated with T2D complications were estimated with the multivariable generalized estimating equations models adjusting for individual characteristics.</p> <p> </p> <p><b>Results:</b></p> <p>The mean annual healthcare cost was $281 and $298 (2017 U.S. dollars) for a male and female, respectively, diagnosed with T2D at age <50 years, with diabetes duration of <5 years, and without comorbidities, antidiabetic treatments, and complications. Depression was the costliest comorbidity, increasing costs by 64-82%. Antidiabetic treatments increased costs by 72-126%. For non-fatal complications, costs increased from 36% (retinopathy) to 202% (stroke) in the event year, and from 13% (retinopathy or neuropathy) to 49% (heart failure) in subsequent years. Costs for the five leading costly non-fatal subtype complications increased by 201-599% (end-stage renal disease with dialysis), 37-376% (hemorrhagic/ischemic stroke), and 13-279% (upper/lower extremity amputation). For fatal complications, costs increased by 1,784-2,001% and 1,285-1,584% for cardiovascular and other-cause deaths, respectively.</p> <p> </p> <p><b>Conclusions:</b></p> <p>The cost estimates from this study are crucial for parameterizing diabetes economic simulation models to quantify the economic impact of clinical outcomes and determine cost-effective interventions.</p>" @default.
- W4252554796 created "2022-05-12" @default.
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- W4252554796 date "2020-05-22" @default.
- W4252554796 modified "2023-10-06" @default.
- W4252554796 title "Healthcare costs associated with macrovascular, microvascular, and metabolic complications of type 2 diabetes across time: Estimates from a population-based cohort of over 0.8 million individuals with up to 15 years of follow-up" @default.
- W4252554796 doi "https://doi.org/10.2337/figshare.12173988" @default.
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