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- W4252812362 abstract "Abstract Present study is involved in identification of biophenolic and flavonoids from the aqueous-ethanol extract of Cyperus iria and appraisal of inflammatory and stress markers involved in endocrine dysfunction based upon its folktale use. Significantly higher quantities of phenolic (82.79 ± 0.003 mg/g GAE) and flavonoid (13.61 ± 0.002 mg/g QE) contents were present. Inhibitory concentration (IC50) exhibited an excellent potential for both antioxidant (IC50 = 3.22 µg/mL) and alpha amylase (IC50 = 36.29 µg/mL) inhibitory assays. High performance liquid chromatography (HPLC), confirmed the existence of myercetin, quercetin, kaempferol and ferullic acid. Cyperus iria aqueous-ethanol extract exhibits good tolerance against glucose. Streptozotocin induced hyperglycemia declined along with improvement in inflammatory (TNF-α = 15.6 ± 0.2 g/l, COX-2 = 357 ± 0.396 U/l, IL-6 = 572 ± 0.99 pg/l) and oxidative stress markers (SOD = 163 ± 0.616 and GSH-ST = 95.8 ± 0.44 U/mL) along with biochemical parameters in a dose-dependent manner. Present study suggests that Cyperus iria aqueous-ethanol extract possess hypoglycemic potential which might be attributed to the presence of phenolics and flavonoids." @default.
- W4252812362 created "2022-05-12" @default.
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- W4252812362 date "2021-02-24" @default.
- W4252812362 modified "2023-09-26" @default.
- W4252812362 title "Cyperus Iria Aqueous-Ethanol Extract Ameliorated Hyperglycemia, Oxidative Stress and Regulated Inflammatory Cytokines in Streptozotocin Induced Diabetic Rats" @default.
- W4252812362 doi "https://doi.org/10.21203/rs.3.rs-216684/v1" @default.
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