Matches in SemOpenAlex for { <https://semopenalex.org/work/W4252824911> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4252824911 endingPage "115" @default.
- W4252824911 startingPage "113" @default.
- W4252824911 abstract "Lipopolysaccharide (LPS) is known to bind to several surface molecules on various cells. The best characterized LPS-binding protein is CD14, strongly expressed in the majority of monocytes. Since CD14 is a glycosylphosphatidyl-inositol (GPI)-anchor protein without a cytoplasmic tail, it has been suggested that additional signalling receptors co-associate with CD14 in order to initiate signal transduction cascades. Here we show that after ligand binding in human blood monocytes, the b2-integrin CD11b/CD18 forms clusters with CD14, after ligand binding. Thus, in response to LPS stimulation a receptor complex is formed in the plane of the plasma membrane which may be of central importance for cellular responses to LPS. We also show that another physiologically relevant ligand of CD14, ceramide, which is structurally similar to LPS, induces a complex of CD14 and CD11b/CD18 after binding to CD14." @default.
- W4252824911 created "2022-05-12" @default.
- W4252824911 creator A5007171804 @default.
- W4252824911 creator A5015453244 @default.
- W4252824911 creator A5030759777 @default.
- W4252824911 creator A5036652138 @default.
- W4252824911 creator A5054041312 @default.
- W4252824911 creator A5067321005 @default.
- W4252824911 creator A5074475221 @default.
- W4252824911 creator A5075797041 @default.
- W4252824911 creator A5089136402 @default.
- W4252824911 creator A5091328249 @default.
- W4252824911 date "2001-07-01" @default.
- W4252824911 modified "2023-10-14" @default.
- W4252824911 title "The Cholesterol Content of the Plasma Membrane as a Regulator of CD14 Dependent Signal Transduction" @default.
- W4252824911 doi "https://doi.org/10.1002/1438-5171(200107)2:2<113::aid-simo113>3.3.co;2-w" @default.
- W4252824911 hasPublicationYear "2001" @default.
- W4252824911 type Work @default.
- W4252824911 citedByCount "0" @default.
- W4252824911 crossrefType "journal-article" @default.
- W4252824911 hasAuthorship W4252824911A5007171804 @default.
- W4252824911 hasAuthorship W4252824911A5015453244 @default.
- W4252824911 hasAuthorship W4252824911A5030759777 @default.
- W4252824911 hasAuthorship W4252824911A5036652138 @default.
- W4252824911 hasAuthorship W4252824911A5054041312 @default.
- W4252824911 hasAuthorship W4252824911A5067321005 @default.
- W4252824911 hasAuthorship W4252824911A5074475221 @default.
- W4252824911 hasAuthorship W4252824911A5075797041 @default.
- W4252824911 hasAuthorship W4252824911A5089136402 @default.
- W4252824911 hasAuthorship W4252824911A5091328249 @default.
- W4252824911 hasConcept C104317684 @default.
- W4252824911 hasConcept C116569031 @default.
- W4252824911 hasConcept C170493617 @default.
- W4252824911 hasConcept C185592680 @default.
- W4252824911 hasConcept C203014093 @default.
- W4252824911 hasConcept C2778513237 @default.
- W4252824911 hasConcept C2778754761 @default.
- W4252824911 hasConcept C55493867 @default.
- W4252824911 hasConcept C62478195 @default.
- W4252824911 hasConcept C6929976 @default.
- W4252824911 hasConcept C86803240 @default.
- W4252824911 hasConcept C95444343 @default.
- W4252824911 hasConceptScore W4252824911C104317684 @default.
- W4252824911 hasConceptScore W4252824911C116569031 @default.
- W4252824911 hasConceptScore W4252824911C170493617 @default.
- W4252824911 hasConceptScore W4252824911C185592680 @default.
- W4252824911 hasConceptScore W4252824911C203014093 @default.
- W4252824911 hasConceptScore W4252824911C2778513237 @default.
- W4252824911 hasConceptScore W4252824911C2778754761 @default.
- W4252824911 hasConceptScore W4252824911C55493867 @default.
- W4252824911 hasConceptScore W4252824911C62478195 @default.
- W4252824911 hasConceptScore W4252824911C6929976 @default.
- W4252824911 hasConceptScore W4252824911C86803240 @default.
- W4252824911 hasConceptScore W4252824911C95444343 @default.
- W4252824911 hasIssue "2" @default.
- W4252824911 hasLocation W42528249111 @default.
- W4252824911 hasOpenAccess W4252824911 @default.
- W4252824911 hasPrimaryLocation W42528249111 @default.
- W4252824911 hasRelatedWork W1974055405 @default.
- W4252824911 hasRelatedWork W1976164254 @default.
- W4252824911 hasRelatedWork W2054917172 @default.
- W4252824911 hasRelatedWork W2073617212 @default.
- W4252824911 hasRelatedWork W2086852627 @default.
- W4252824911 hasRelatedWork W2110745616 @default.
- W4252824911 hasRelatedWork W2188692751 @default.
- W4252824911 hasRelatedWork W2530344549 @default.
- W4252824911 hasRelatedWork W4232966056 @default.
- W4252824911 hasRelatedWork W4243082057 @default.
- W4252824911 hasVolume "2" @default.
- W4252824911 isParatext "false" @default.
- W4252824911 isRetracted "false" @default.
- W4252824911 workType "article" @default.