Matches in SemOpenAlex for { <https://semopenalex.org/work/W4252931792> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4252931792 endingPage "3445" @default.
- W4252931792 startingPage "3438" @default.
- W4252931792 abstract "Simian virus 40-based plasmids that direct the synthesis of preproinsulin during short-term transfection of COS cells have been used to probe the mechanism of reinitiation by eucaryotic ribosomes. Earlier studies from several laboratories had established that the ability of ribosomes to reinitiate translation at an internal AUG codon depends on having a terminator codon in frame with the preceding AUG triplet and upstream from the intended restart site. In the present studies, the position of the upstream terminator codon relative to the preproinsulin restart site has been systematically varied. The efficiency of reinitiation progressively improved as the intercistronic sequence was lengthened. When the upstream minicistron terminated 79 nucleotides before the preproinsulin start site, the synthesis of proinsulin was as efficient as if there were no upstream AUG codons. A mechanism is postulated that might account for this result, which is somewhat surprising inasmuch as bacterial ribosomes reinitiate less efficiently as the intercistronic gap is widened." @default.
- W4252931792 created "2022-05-12" @default.
- W4252931792 creator A5023781524 @default.
- W4252931792 date "1987-10-01" @default.
- W4252931792 modified "2023-10-09" @default.
- W4252931792 title "Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes." @default.
- W4252931792 doi "https://doi.org/10.1128/mcb.7.10.3438" @default.
- W4252931792 hasPublicationYear "1987" @default.
- W4252931792 type Work @default.
- W4252931792 citedByCount "252" @default.
- W4252931792 countsByYear W42529317922012 @default.
- W4252931792 countsByYear W42529317922013 @default.
- W4252931792 countsByYear W42529317922014 @default.
- W4252931792 countsByYear W42529317922015 @default.
- W4252931792 countsByYear W42529317922016 @default.
- W4252931792 countsByYear W42529317922017 @default.
- W4252931792 countsByYear W42529317922018 @default.
- W4252931792 countsByYear W42529317922019 @default.
- W4252931792 countsByYear W42529317922020 @default.
- W4252931792 countsByYear W42529317922021 @default.
- W4252931792 countsByYear W42529317922022 @default.
- W4252931792 countsByYear W42529317922023 @default.
- W4252931792 crossrefType "journal-article" @default.
- W4252931792 hasAuthorship W4252931792A5023781524 @default.
- W4252931792 hasBestOaLocation W42529317922 @default.
- W4252931792 hasConcept C104317684 @default.
- W4252931792 hasConcept C116403925 @default.
- W4252931792 hasConcept C121332964 @default.
- W4252931792 hasConcept C1276947 @default.
- W4252931792 hasConcept C166258313 @default.
- W4252931792 hasConcept C176990463 @default.
- W4252931792 hasConcept C178046730 @default.
- W4252931792 hasConcept C20580545 @default.
- W4252931792 hasConcept C22744801 @default.
- W4252931792 hasConcept C512185932 @default.
- W4252931792 hasConcept C54355233 @default.
- W4252931792 hasConcept C552990157 @default.
- W4252931792 hasConcept C55334214 @default.
- W4252931792 hasConcept C67705224 @default.
- W4252931792 hasConcept C86803240 @default.
- W4252931792 hasConcept C88478588 @default.
- W4252931792 hasConceptScore W4252931792C104317684 @default.
- W4252931792 hasConceptScore W4252931792C116403925 @default.
- W4252931792 hasConceptScore W4252931792C121332964 @default.
- W4252931792 hasConceptScore W4252931792C1276947 @default.
- W4252931792 hasConceptScore W4252931792C166258313 @default.
- W4252931792 hasConceptScore W4252931792C176990463 @default.
- W4252931792 hasConceptScore W4252931792C178046730 @default.
- W4252931792 hasConceptScore W4252931792C20580545 @default.
- W4252931792 hasConceptScore W4252931792C22744801 @default.
- W4252931792 hasConceptScore W4252931792C512185932 @default.
- W4252931792 hasConceptScore W4252931792C54355233 @default.
- W4252931792 hasConceptScore W4252931792C552990157 @default.
- W4252931792 hasConceptScore W4252931792C55334214 @default.
- W4252931792 hasConceptScore W4252931792C67705224 @default.
- W4252931792 hasConceptScore W4252931792C86803240 @default.
- W4252931792 hasConceptScore W4252931792C88478588 @default.
- W4252931792 hasIssue "10" @default.
- W4252931792 hasLocation W42529317921 @default.
- W4252931792 hasLocation W42529317922 @default.
- W4252931792 hasLocation W42529317923 @default.
- W4252931792 hasOpenAccess W4252931792 @default.
- W4252931792 hasPrimaryLocation W42529317921 @default.
- W4252931792 hasRelatedWork W106097148 @default.
- W4252931792 hasRelatedWork W1976105576 @default.
- W4252931792 hasRelatedWork W2005952992 @default.
- W4252931792 hasRelatedWork W2025717469 @default.
- W4252931792 hasRelatedWork W2096534335 @default.
- W4252931792 hasRelatedWork W2099390806 @default.
- W4252931792 hasRelatedWork W2100776225 @default.
- W4252931792 hasRelatedWork W2502789821 @default.
- W4252931792 hasRelatedWork W2946901484 @default.
- W4252931792 hasRelatedWork W4252931792 @default.
- W4252931792 hasVolume "7" @default.
- W4252931792 isParatext "false" @default.
- W4252931792 isRetracted "false" @default.
- W4252931792 workType "article" @default.