Matches in SemOpenAlex for { <https://semopenalex.org/work/W4252946937> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4252946937 abstract "Abstract In the present study, we investigated the distribution of genetic variations in IL6 and IL6R genes, which may be employed as prognostic and pharmacogenetic biomarkers for COVID-19 and neurodegenerative diseases. The study was performed on 271 samples representative of the Italian general population and identified seven variants (rs140764737, rs142164099, rs2069849, rs142759801, rs190436077, rs148171375, rs13306435) in IL6 and five variants (rs2228144, rs2229237, rs2228145, rs28730735, rs143810642) within IL6R , respectively. These variants have been predicted to affect the expression and binding ability of IL6 and IL6R. The Ingenuity Pathway Analysis (IPA) showed that IL6 and IL6R appeared to be implicated in several pathogenetic mechanisms associated with COVID19 severity and mortality as well as with neurodegenerative diseases mediated by neuroinflammation. Thus, the availability of IL6-IL6R-related biomarkers for COVID19 disease may be helpful to counteract harmful complications and prevent multi-organ failure. At the same time, IL6-IL6R-related biomarkers could also be useful for assessing the susceptibility and progression of neuroinflammatory disorders and undertake the most suitable treatment strategies to improve patients’ prognosis and quality of life. In conclusion, this study showed how IL6 pleiotropic activity could be exploited to meet different clinical needs and realize precision medicine protocols for chronic, age-related and modern public health emergencies." @default.
- W4252946937 created "2022-05-12" @default.
- W4252946937 creator A5021425942 @default.
- W4252946937 creator A5022690163 @default.
- W4252946937 creator A5030637179 @default.
- W4252946937 creator A5055893797 @default.
- W4252946937 creator A5062548065 @default.
- W4252946937 creator A5064005384 @default.
- W4252946937 creator A5080843385 @default.
- W4252946937 date "2020-09-16" @default.
- W4252946937 modified "2023-10-18" @default.
- W4252946937 title "Investigation of genetic variations of IL6 and IL6R as potential prognostic and pharmacogenetics biomarkers: implications for COVID19 and neuroinflammatory disorders." @default.
- W4252946937 doi "https://doi.org/10.21203/rs.3.rs-77342/v1" @default.
- W4252946937 hasPublicationYear "2020" @default.
- W4252946937 type Work @default.
- W4252946937 citedByCount "3" @default.
- W4252946937 countsByYear W42529469372022 @default.
- W4252946937 countsByYear W42529469372023 @default.
- W4252946937 crossrefType "posted-content" @default.
- W4252946937 hasAuthorship W4252946937A5021425942 @default.
- W4252946937 hasAuthorship W4252946937A5022690163 @default.
- W4252946937 hasAuthorship W4252946937A5030637179 @default.
- W4252946937 hasAuthorship W4252946937A5055893797 @default.
- W4252946937 hasAuthorship W4252946937A5062548065 @default.
- W4252946937 hasAuthorship W4252946937A5064005384 @default.
- W4252946937 hasAuthorship W4252946937A5080843385 @default.
- W4252946937 hasBestOaLocation W42529469371 @default.
- W4252946937 hasConcept C104317684 @default.
- W4252946937 hasConcept C11988809 @default.
- W4252946937 hasConcept C126322002 @default.
- W4252946937 hasConcept C133425853 @default.
- W4252946937 hasConcept C135763542 @default.
- W4252946937 hasConcept C142724271 @default.
- W4252946937 hasConcept C162324750 @default.
- W4252946937 hasConcept C163763905 @default.
- W4252946937 hasConcept C170734499 @default.
- W4252946937 hasConcept C2776914184 @default.
- W4252946937 hasConcept C2778154381 @default.
- W4252946937 hasConcept C2779134260 @default.
- W4252946937 hasConcept C2781197716 @default.
- W4252946937 hasConcept C54355233 @default.
- W4252946937 hasConcept C55775858 @default.
- W4252946937 hasConcept C60644358 @default.
- W4252946937 hasConcept C71924100 @default.
- W4252946937 hasConcept C86803240 @default.
- W4252946937 hasConcept C87753298 @default.
- W4252946937 hasConcept C98274493 @default.
- W4252946937 hasConceptScore W4252946937C104317684 @default.
- W4252946937 hasConceptScore W4252946937C11988809 @default.
- W4252946937 hasConceptScore W4252946937C126322002 @default.
- W4252946937 hasConceptScore W4252946937C133425853 @default.
- W4252946937 hasConceptScore W4252946937C135763542 @default.
- W4252946937 hasConceptScore W4252946937C142724271 @default.
- W4252946937 hasConceptScore W4252946937C162324750 @default.
- W4252946937 hasConceptScore W4252946937C163763905 @default.
- W4252946937 hasConceptScore W4252946937C170734499 @default.
- W4252946937 hasConceptScore W4252946937C2776914184 @default.
- W4252946937 hasConceptScore W4252946937C2778154381 @default.
- W4252946937 hasConceptScore W4252946937C2779134260 @default.
- W4252946937 hasConceptScore W4252946937C2781197716 @default.
- W4252946937 hasConceptScore W4252946937C54355233 @default.
- W4252946937 hasConceptScore W4252946937C55775858 @default.
- W4252946937 hasConceptScore W4252946937C60644358 @default.
- W4252946937 hasConceptScore W4252946937C71924100 @default.
- W4252946937 hasConceptScore W4252946937C86803240 @default.
- W4252946937 hasConceptScore W4252946937C87753298 @default.
- W4252946937 hasConceptScore W4252946937C98274493 @default.
- W4252946937 hasLocation W42529469371 @default.
- W4252946937 hasLocation W42529469372 @default.
- W4252946937 hasOpenAccess W4252946937 @default.
- W4252946937 hasPrimaryLocation W42529469371 @default.
- W4252946937 hasRelatedWork W1987948216 @default.
- W4252946937 hasRelatedWork W2025838170 @default.
- W4252946937 hasRelatedWork W2330870561 @default.
- W4252946937 hasRelatedWork W2596563114 @default.
- W4252946937 hasRelatedWork W2753240051 @default.
- W4252946937 hasRelatedWork W3106860414 @default.
- W4252946937 hasRelatedWork W3211470828 @default.
- W4252946937 hasRelatedWork W4252946937 @default.
- W4252946937 hasRelatedWork W4253339674 @default.
- W4252946937 hasRelatedWork W4285265853 @default.
- W4252946937 isParatext "false" @default.
- W4252946937 isRetracted "false" @default.
- W4252946937 workType "article" @default.