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- W4252948571 abstract "Duration of Immunization against Diphtheria H. Lyndhurst Duke and W. B. Stott (Brit. Med. J., 710; Dec. 4, 1943) have published a paper of interest to all who have followed the Ministry of Health's advice that children—and especially children under five—should be immunized against diphtheria. They have studied the duration of artificial immunity to diphtheria in the Cuckfield and Burgess Hill areas, which have a child population of 9,600 children aged 1–15 years, 95 per cent of whom have been immunized as a result of a campaign started in 1936 by Dr. Stott. A large number of children under five were immunized. Material was therefore available for the study! of the duration of the immunity, and more than 3,000 children were tested by the Schick test 2–6 years after immunization. The authors found that the number of children who lost their immunity rose steadily as time went on; after two years 4 per cent, and after six years 18 per cent had lost it. They conclude that it is important to test children some two years after the completion of the immunization. Boys and girls differ little in their response to the antigen. In great cities some 50–70 per cent of children may become naturally negative to the Schick test, but in rural areas natural Schick-negatives may be few, and in the area studied there was no evidence among children under five that such natural immunization had developed. Discussing the question of diphtheria carriers, the authors state their view that, year by year, as the campaign for immunization against diphtheria goes on, a large body of potential carriers is being formed, and that this has probably already built up the natural or artificially acquired level of immunity and acts as a buffer against large-scale introduction of new sources of the infection. It is important to remember that artificial immunization protects against the toxin which causes the symptoms, but not against the bacillus." @default.
- W4252948571 created "2022-05-12" @default.
- W4252948571 date "1944-03-01" @default.
- W4252948571 modified "2023-09-27" @default.
- W4252948571 title "Research Items" @default.
- W4252948571 doi "https://doi.org/10.1038/153318a0" @default.
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