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- W4252968138 abstract "Abstract Purpose Preoperative differentiation of prosthetic joint infection (PJI) and aseptic loosening (AL) is challenging. We aimed to evaluate the utility of visual analysis and semi-quantitative parameters of [ 68 Ga]Ga-citrate positron emission tomography/computed tomography (PET/CT) in the differentiation of PJI and AL. Methods Sixteen patients with suspected PJI or AL underwent [ 68 Ga]Ga-citrate PET/CT imaging. Results were evaluated by three nuclear medicine doctors based on (1) visual analysis of the attenuation correction (AC) and non-attenuation correction (NAC) based on tracer uptake intensity and range; (2) maximum standard uptake value (SUVmax) of lesions and the SUVmax of the target area/SUVmax of the non-target area (bone and muscle; T/NT [bone] and T/NT [muscle]). The final diagnosis was based on the Musculoskeletal Infection Society criteria, intraoperative findings, and histopathological and microbiological examinations. Results Overall, 10 (62.5%) and 6 (37.5%) patients were diagnosed with PJI and AL, respectively. Receiver operating characteristic analysis revealed that the areas under the curve for SUVmax, T/NT (bone), and T/NT (muscle) were 0.617 (cut-off = 2.243, P = 0.4312), 0.850 (cut-off = 2.844, P = 0.0052), and 0.850 (cut-off = 5.983, P = 0.0003), respectively. AC, NAC, and T/NT (bone) exhibited high differential diagnostic values (sensitivity, specificity, and accuracy of 90.0%, 83.3%, and 87.5%, respectively). The diagnostic efficacy of T/NT (muscle) was the second highest (sensitivity, specificity, and accuracy of 60.0%, 100%, and 75.0%, respectively). SUVmax demonstrated the poorest diagnostic efficacy (sensitivity, specificity, and accuracy of 70.0%, 66.7%, and 68.8%, respectively). Conclusion Our results suggest that [ 68 Ga]Ga-citrate may differentiate PJI and AL." @default.
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- W4252968138 date "2020-10-19" @default.
- W4252968138 modified "2023-09-27" @default.
- W4252968138 title "Application of [68Ga]Ga-citrate PET/CT for Differentiating Prosthetic Joint Infection from Aseptic Loosening After Joint Replacement Surgery" @default.
- W4252968138 doi "https://doi.org/10.21203/rs.3.rs-81449/v1" @default.
- W4252968138 hasPublicationYear "2020" @default.
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