FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253059207> ?p ?o ?g. }

• W4253059207 endingPage "194" @default.
• W4253059207 startingPage "187" @default.
• W4253059207 abstract "p300/CBP-associated factor (PCAF) is a coactivator of the tumor suppressor, p53. PCAF participates in p53's transactivation of target genes through acetylation of both bound p53 and histones within p53 target promoters. Using microarrays, we discovered that PCAF itself is induced by p53 in a panel of breast tumor cell lines. Two p53 mutant breast tumor cell lines, BT-549 and UACC-1179, were chosen for further study of PCAF induction by wild-type p53. PCAF induction following adenoviral transduction of p53 expression was confirmed with real-time polymerase chain reaction in a time course experiment. Chromatin immunoprecipitation experiments then showed that PCAF induction was associated with increased p53 binding to the PCAF promoter, which contains p53 consensus-binding sites. PCAF induction by p53 activity was further demonstrated in wild-type p53 MCF10A cells when PCAF expression was induced following activation of endogenous wild-type p53 with doxorubicin in a dose- and time-dependent manner. Furthermore, the doxorubicin-induced increase in PCAF expression was blocked by pretreatment of the MCF10A cells with siRNA (small interfering RNA) targeted against p53 mRNA. Taken together, the results show that PCAF expression can be induced by wild-type p53." @default.
• W4253059207 created "2022-05-12" @default.
• W4253059207 creator A5029797248 @default.
• W4253059207 creator A5054621218 @default.
• W4253059207 creator A5058298813 @default.
• W4253059207 creator A5060046254 @default.
• W4253059207 creator A5070049424 @default.
• W4253059207 creator A5073608763 @default.
• W4253059207 creator A5074277665 @default.
• W4253059207 date "2004-05-01" @default.
• W4253059207 modified "2023-09-27" @default.
• W4253059207 title "The Acetyltransferase p300/CBP-Associated Factor Is a p53 Target Gene in Breast Tumor Cells" @default.
• W4253059207 cites W1650797637 @default.
• W4253059207 cites W1657827244 @default.
• W4253059207 cites W1969844290 @default.
• W4253059207 cites W1971966311 @default.
• W4253059207 cites W1973669584 @default.
• W4253059207 cites W1985063313 @default.
• W4253059207 cites W1991494214 @default.
• W4253059207 cites W2002704525 @default.
• W4253059207 cites W2021787959 @default.
• W4253059207 cites W2034562270 @default.
• W4253059207 cites W2065646551 @default.
• W4253059207 cites W2074222004 @default.
• W4253059207 cites W2081940450 @default.
• W4253059207 cites W2092722802 @default.
• W4253059207 cites W2095050846 @default.
• W4253059207 cites W2095217266 @default.
• W4253059207 cites W2111447146 @default.
• W4253059207 cites W2160872319 @default.
• W4253059207 cites W2162487261 @default.
• W4253059207 cites W4253422011 @default.
• W4253059207 doi "https://doi.org/10.1593/neo.03292" @default.
• W4253059207 hasPublicationYear "2004" @default.
• W4253059207 type Work @default.
• W4253059207 citedByCount "32" @default.
• W4253059207 countsByYear W42530592072012 @default.
• W4253059207 countsByYear W42530592072013 @default.
• W4253059207 countsByYear W42530592072016 @default.
• W4253059207 countsByYear W42530592072018 @default.
• W4253059207 countsByYear W42530592072019 @default.
• W4253059207 countsByYear W42530592072021 @default.
• W4253059207 countsByYear W42530592072023 @default.
• W4253059207 crossrefType "journal-article" @default.
• W4253059207 hasAuthorship W4253059207A5029797248 @default.
• W4253059207 hasAuthorship W4253059207A5054621218 @default.
• W4253059207 hasAuthorship W4253059207A5058298813 @default.
• W4253059207 hasAuthorship W4253059207A5060046254 @default.
• W4253059207 hasAuthorship W4253059207A5070049424 @default.
• W4253059207 hasAuthorship W4253059207A5073608763 @default.
• W4253059207 hasAuthorship W4253059207A5074277665 @default.
• W4253059207 hasBestOaLocation W42530592071 @default.
• W4253059207 hasConcept C101762097 @default.
• W4253059207 hasConcept C104317684 @default.
• W4253059207 hasConcept C107793267 @default.
• W4253059207 hasConcept C119157956 @default.
• W4253059207 hasConcept C1292079 @default.
• W4253059207 hasConcept C134320426 @default.
• W4253059207 hasConcept C150194340 @default.
• W4253059207 hasConcept C153911025 @default.
• W4253059207 hasConcept C2779649592 @default.
• W4253059207 hasConcept C2910921701 @default.
• W4253059207 hasConcept C2911110750 @default.
• W4253059207 hasConcept C502942594 @default.
• W4253059207 hasConcept C54355233 @default.
• W4253059207 hasConcept C64927066 @default.
• W4253059207 hasConcept C77445288 @default.
• W4253059207 hasConcept C86339819 @default.
• W4253059207 hasConcept C86803240 @default.
• W4253059207 hasConceptScore W4253059207C101762097 @default.
• W4253059207 hasConceptScore W4253059207C104317684 @default.
• W4253059207 hasConceptScore W4253059207C107793267 @default.
• W4253059207 hasConceptScore W4253059207C119157956 @default.
• W4253059207 hasConceptScore W4253059207C1292079 @default.
• W4253059207 hasConceptScore W4253059207C134320426 @default.
• W4253059207 hasConceptScore W4253059207C150194340 @default.
• W4253059207 hasConceptScore W4253059207C153911025 @default.
• W4253059207 hasConceptScore W4253059207C2779649592 @default.
• W4253059207 hasConceptScore W4253059207C2910921701 @default.
• W4253059207 hasConceptScore W4253059207C2911110750 @default.
• W4253059207 hasConceptScore W4253059207C502942594 @default.
• W4253059207 hasConceptScore W4253059207C54355233 @default.
• W4253059207 hasConceptScore W4253059207C64927066 @default.
• W4253059207 hasConceptScore W4253059207C77445288 @default.
• W4253059207 hasConceptScore W4253059207C86339819 @default.
• W4253059207 hasConceptScore W4253059207C86803240 @default.
• W4253059207 hasIssue "3" @default.
• W4253059207 hasLocation W42530592071 @default.
• W4253059207 hasLocation W42530592072 @default.
• W4253059207 hasOpenAccess W4253059207 @default.
• W4253059207 hasPrimaryLocation W42530592071 @default.
• W4253059207 hasRelatedWork W1972105214 @default.
• W4253059207 hasRelatedWork W1972791523 @default.
• W4253059207 hasRelatedWork W2036370282 @default.
• W4253059207 hasRelatedWork W2052296178 @default.
• W4253059207 hasRelatedWork W2078673393 @default.
• W4253059207 hasRelatedWork W2087646825 @default.
• W4253059207 hasRelatedWork W2093396808 @default.

• next