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- W4253092008 abstract "Abstract Background: The immune response plays a critical role in gastric cancer (GC) initiation, progression, metastasis, and response to therapy. A better understanding of the tumor-immune system interactions in GC may provide promising diagnostic, prognostic, and therapeutic biomarkers for patients with this disease. In the present study, we aimed to identify a prognostic signature of GC through a comprehensive bioinformatics analysis on the tumor-immune interactions as well as the molecular characteristics. Methods: We employed the single sample Gene Sets Enrichment Analysis (ssGSEA) to define immune-related subtypes, used Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data (ESTIMATE) to evaluate the content of tumor and stroma, and utilized Cell type Identification By Estimating Relative Subsets of RNA Transcripts (CIBERSORT) to assess the immune cell type infiltration. We also investigated the complicated biological functions and regulatory networks of these subtypes using Gene Sets Enrichment Analysis (GSEA). Next, we developed a risk model using Lasso Cox regression and verified it via the external validation set. Finally, we systematically correlated the immune signature with GC clinicopathologic features and genomic characteristics. Results: We observed two immune subgroups depending on the activity and level of immune cell in GC patients. We also identified a six-immune-gene signature as a promising independent prognostic biomarker for GC. A nomogram was constructed based on the immune signature and clinical characteristics and showed high potential for GC prognosis prediction. The receiver operating characteristic (ROC) curve analysis distinguishing patients with distinct prognosis yielded an area under the curve (AUC) of 0.779 for 5 years. Conclusions: Our work supports the clinical significance of this immune gene-associated signature for predicting the prognosis of GC patients. This study also shed light on the treatment strategies for GC patients from the perspective of immunology." @default.
- W4253092008 created "2022-05-12" @default.
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- W4253092008 date "2020-11-04" @default.
- W4253092008 modified "2023-09-30" @default.
- W4253092008 title "Identification of an Immune Gene-Associated Prognostic Signature and its Association with A Poor Prognosis in Gastric Cancer Patients" @default.
- W4253092008 doi "https://doi.org/10.21203/rs.3.rs-100293/v1" @default.
- W4253092008 hasPublicationYear "2020" @default.
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