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• W4253135016 abstract "Purpose/ObjectiveTo evaluate the accuracy of image coregistration of PET-CT images in patients with non-small cell lung cancer and investigate the impact of PET-CT image coregistration on radiation treatment planning.Materials/Methods13 patients with well-circumscribed non-small cell lung cancer lesions were examined by in-lined PET-CT. The registration accuracy of PET-CT were measured with two methods?volume measure and center of geometry (COG) measure. The volume of interest of each lesion was defined separately on PET, CT and fused images, VPET, VCT, VPET+CT. The overlap volume of PET and CT images was calculated with formula: VPET-CT=VPET+VCT-VPET+CT. The percentage of VPET-CT on VPET+CT, PPET-CT was used to assess the fusion accuracy of PET and CT images. The geometric center of gravity (COG) of VPET and VCT was assessed. The distance of COGs between the PET image and the CT images, DCOG was measured. The image data were transferred to the radiation treatment planning system. Three plans were performed according to different volume, VPET, VCT, VPET+CT, with a prescribed dose of 60Gy. The dose of lung, heart and spinal cord were recorded in plans and compared with each other.ResultsThe mean of DCOG was .95mm ± 2.41mm(1.00mm ∼8.68mm). PPET-CT was 46.69 ± 19.21%(2.65%∼70.41%). Misregistration tended to be more pronounced in the lower lungs (n = 7, DCOG=4.73mm ± 2.50mm, PPET-CT=52.00% ± 23.62%) than in the upper lungs (n = 6, DCOG=5.21mm ± 2.51mm, PPET-CT=49.49% ± 11.40%) (P > 0.05). The doses to lung (mean lung dose and V20) and maximal doses to spinal cord and heart were higher in plans according to the VPET+CT than in those according to the VPET and VCT(P < 0.05), but there was no statistical difference among the mean doses to heart and spinal cord in three plans (P > 0.05). The data were shown in the table 1(table 1).Conclusions Purpose/ObjectiveTo evaluate the accuracy of image coregistration of PET-CT images in patients with non-small cell lung cancer and investigate the impact of PET-CT image coregistration on radiation treatment planning. To evaluate the accuracy of image coregistration of PET-CT images in patients with non-small cell lung cancer and investigate the impact of PET-CT image coregistration on radiation treatment planning. Materials/Methods13 patients with well-circumscribed non-small cell lung cancer lesions were examined by in-lined PET-CT. The registration accuracy of PET-CT were measured with two methods?volume measure and center of geometry (COG) measure. The volume of interest of each lesion was defined separately on PET, CT and fused images, VPET, VCT, VPET+CT. The overlap volume of PET and CT images was calculated with formula: VPET-CT=VPET+VCT-VPET+CT. The percentage of VPET-CT on VPET+CT, PPET-CT was used to assess the fusion accuracy of PET and CT images. The geometric center of gravity (COG) of VPET and VCT was assessed. The distance of COGs between the PET image and the CT images, DCOG was measured. The image data were transferred to the radiation treatment planning system. Three plans were performed according to different volume, VPET, VCT, VPET+CT, with a prescribed dose of 60Gy. The dose of lung, heart and spinal cord were recorded in plans and compared with each other. 13 patients with well-circumscribed non-small cell lung cancer lesions were examined by in-lined PET-CT. The registration accuracy of PET-CT were measured with two methods?volume measure and center of geometry (COG) measure. The volume of interest of each lesion was defined separately on PET, CT and fused images, VPET, VCT, VPET+CT. The overlap volume of PET and CT images was calculated with formula: VPET-CT=VPET+VCT-VPET+CT. The percentage of VPET-CT on VPET+CT, PPET-CT was used to assess the fusion accuracy of PET and CT images. The geometric center of gravity (COG) of VPET and VCT was assessed. The distance of COGs between the PET image and the CT images, DCOG was measured. The image data were transferred to the radiation treatment planning system. Three plans were performed according to different volume, VPET, VCT, VPET+CT, with a prescribed dose of 60Gy. The dose of lung, heart and spinal cord were recorded in plans and compared with each other. ResultsThe mean of DCOG was .95mm ± 2.41mm(1.00mm ∼8.68mm). PPET-CT was 46.69 ± 19.21%(2.65%∼70.41%). Misregistration tended to be more pronounced in the lower lungs (n = 7, DCOG=4.73mm ± 2.50mm, PPET-CT=52.00% ± 23.62%) than in the upper lungs (n = 6, DCOG=5.21mm ± 2.51mm, PPET-CT=49.49% ± 11.40%) (P > 0.05). The doses to lung (mean lung dose and V20) and maximal doses to spinal cord and heart were higher in plans according to the VPET+CT than in those according to the VPET and VCT(P < 0.05), but there was no statistical difference among the mean doses to heart and spinal cord in three plans (P > 0.05). The data were shown in the table 1(table 1). The mean of DCOG was .95mm ± 2.41mm(1.00mm ∼8.68mm). PPET-CT was 46.69 ± 19.21%(2.65%∼70.41%). Misregistration tended to be more pronounced in the lower lungs (n = 7, DCOG=4.73mm ± 2.50mm, PPET-CT=52.00% ± 23.62%) than in the upper lungs (n = 6, DCOG=5.21mm ± 2.51mm, PPET-CT=49.49% ± 11.40%) (P > 0.05). The doses to lung (mean lung dose and V20) and maximal doses to spinal cord and heart were higher in plans according to the VPET+CT than in those according to the VPET and VCT(P < 0.05), but there was no statistical difference among the mean doses to heart and spinal cord in three plans (P > 0.05). The data were shown in the table 1(table 1). 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• W4253135016 date "2004-09-01" @default.
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• W4253135016 title "The impact of PET-CT image coregistration on radiation treatment planning for non-small cell lung cancer" @default.
• W4253135016 doi "https://doi.org/10.1016/s0360-3016(04)01907-8" @default.
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