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• W4253166759 abstract "Many medications of different indications have a relevant anticholinergic activity. The anticholinergic burden of medication has been shown to have significant effects on the cognition and the risk for cognitive impairment and dementia particularly in older patients. So far, most of the studies used data from geriatric patients and the effect of the anticholinergic burden on brain structures is still unexplored. Our study aimed to analyze possible associations of hippocampus and cholinergic basal forebrain (BF) volumes as vulnerable brain structures for the development of dementia and the anticholinergic burden in a population-based cohort of non-demented participants spanning the adult age range from 20 to 80 years. We analyzed partial correlation between structural MRI volumes and medication related anticholinergic burden from participants (n= 2,573, 55.7% female) of the population-based “Study of Health in Pomerania” (SHIP). Anticholinergic burden was obtained from the current medication plan using the Anticholinergic Burden Scale (ACB). Correlations were controlled for age, gender, education and total intracranial volume. Analyzing the entire group we found statistically significant associations between the ACB and the left (p=0.01, r=0.051) and right hippocampus (p=0.04, r=0.041) but not for BF. Complementary voxel-based analysis across all participants revealed FWE-corrected (p=<0.05) cluster in the right hippocampal/parahippocampal region and left temporo-parietal regions reaching into frontal areas showing reduced volumes with increasing ACB scores. To evaluate a potential interaction effect of age and ACB we split the dataset into two age groups (below 60 years and 60 years or older). We found no significant interaction effect of age and ACB on the left or right hippocampus volume. For the BF we observed a slight trend of the interaction effect with a steeper negative association of ACB and BF in the younger age group (p=0.069, F=3.31; Figure 1)." @default.
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• W4253166759 date "2019-07-01" @default.
• W4253166759 modified "2023-09-27" @default.
• W4253166759 title "P2-411: EFFECTS OF ANTICHOLINERGIC BURDEN ON GREY BRAIN MATTER VOLUMES IN A POPULATION-BASED COHORT ACROSS THE ENTIRE ADULT AGE RANGE" @default.
• W4253166759 doi "https://doi.org/10.1016/j.jalz.2019.06.2818" @default.
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