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- W4253182786 abstract "Methylations are widespread in the biological kingdom. However, their chemical and biochemical roles have not been fully dissected. A hypothesis was put forward previously in which methylation is proposed to lead to hyperconjugation, whose electron donating feature weakens the chemical bonds and increases the bond lengths of C-N, therefore resulting in stronger secondary bonding between nitrogen atoms and cations or protonation of nitrogen atoms. Consequently ion homeostasis of the cells is compromised giving rise to certain diseases. Protonation of nitrogen atoms in 5-methyl cytosine enhances interaction with negatively charged phosphate groups and contributes to the formation of heterochromatin." @default.
- W4253182786 created "2022-05-12" @default.
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- W4253182786 date "2020-10-29" @default.
- W4253182786 modified "2023-09-25" @default.
- W4253182786 title "Methyl group, hyperconjugation and human diseases" @default.
- W4253182786 doi "https://doi.org/10.31219/osf.io/xp5eu" @default.
- W4253182786 hasPublicationYear "2020" @default.
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