Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253222912> ?p ?o ?g. }
- W4253222912 endingPage "64s" @default.
- W4253222912 startingPage "60s" @default.
- W4253222912 abstract "A number of DNA sequences specific for collagen messenger RNAs and genes have been isolated, cloned in bacterial plasmids or bacteriophages, and studied in detail. Such sequences have been used to study regulatory mechanisms underlying the production of type I collagen in fibroblasts in culture, fibroblasts after viral transformation, and in tissues and organs during embryonic and fetal development. It is clear that a variety of mechanisms, transcriptional, translational and post-translational, are used by cells to regulate collagen production. The study of isolated collagen gene fragments coding for the alpha 2 collagen chain in sheep and chick have shown that many genes are very large, and are interrupted by as many as 50 intervening sequences. Additionally, the structure of the genes in the regions coding for the helical regions of the protein provides evidence that collagen genes may have arisen from the reduplication of a DNA segment containing a primordial collagen gene sequence. The availability of specific cloned collagen gene sequences will allow the precise chromosomal location of the collagen genes as well as the number and the linkage relationships between these genes. In addition, genetic disorders of connective tissue where alterations in collagen structure are implicated will now be amenable to analysis at the DNA level." @default.
- W4253222912 created "2022-05-12" @default.
- W4253222912 creator A5058896483 @default.
- W4253222912 creator A5064433832 @default.
- W4253222912 date "1982-07-01" @default.
- W4253222912 modified "2023-09-30" @default.
- W4253222912 title "The Collagen Alpha-2 Chain Gene." @default.
- W4253222912 cites W1481547728 @default.
- W4253222912 cites W1484043176 @default.
- W4253222912 cites W1505498207 @default.
- W4253222912 cites W1511090791 @default.
- W4253222912 cites W1525816334 @default.
- W4253222912 cites W1535175660 @default.
- W4253222912 cites W1540517802 @default.
- W4253222912 cites W1558516755 @default.
- W4253222912 cites W1582983825 @default.
- W4253222912 cites W1964592653 @default.
- W4253222912 cites W1969181305 @default.
- W4253222912 cites W1979502863 @default.
- W4253222912 cites W1980528800 @default.
- W4253222912 cites W2002367604 @default.
- W4253222912 cites W2004210704 @default.
- W4253222912 cites W2005463030 @default.
- W4253222912 cites W2007396871 @default.
- W4253222912 cites W2007672823 @default.
- W4253222912 cites W2012911917 @default.
- W4253222912 cites W2014576942 @default.
- W4253222912 cites W2018589800 @default.
- W4253222912 cites W2020684530 @default.
- W4253222912 cites W2021753888 @default.
- W4253222912 cites W2028678028 @default.
- W4253222912 cites W2032343668 @default.
- W4253222912 cites W2035520923 @default.
- W4253222912 cites W2039835981 @default.
- W4253222912 cites W2050740740 @default.
- W4253222912 cites W2054468433 @default.
- W4253222912 cites W2058510931 @default.
- W4253222912 cites W2065717076 @default.
- W4253222912 cites W2067231547 @default.
- W4253222912 cites W2067727842 @default.
- W4253222912 cites W2069758421 @default.
- W4253222912 cites W2074365344 @default.
- W4253222912 cites W2074725926 @default.
- W4253222912 cites W2075024549 @default.
- W4253222912 cites W2081441416 @default.
- W4253222912 cites W2090631455 @default.
- W4253222912 cites W2134019277 @default.
- W4253222912 cites W2138270253 @default.
- W4253222912 cites W2151860884 @default.
- W4253222912 cites W2343241053 @default.
- W4253222912 cites W2414039702 @default.
- W4253222912 cites W4241254126 @default.
- W4253222912 cites W4250307991 @default.
- W4253222912 cites W73502799 @default.
- W4253222912 doi "https://doi.org/10.1111/1523-1747.ep12545778" @default.
- W4253222912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7086191" @default.
- W4253222912 hasPublicationYear "1982" @default.
- W4253222912 type Work @default.
- W4253222912 citedByCount "3" @default.
- W4253222912 crossrefType "journal-article" @default.
- W4253222912 hasAuthorship W4253222912A5058896483 @default.
- W4253222912 hasAuthorship W4253222912A5064433832 @default.
- W4253222912 hasConcept C104317684 @default.
- W4253222912 hasConcept C134018914 @default.
- W4253222912 hasConcept C153911025 @default.
- W4253222912 hasConcept C189165786 @default.
- W4253222912 hasConcept C22744801 @default.
- W4253222912 hasConcept C2780644872 @default.
- W4253222912 hasConcept C38008103 @default.
- W4253222912 hasConcept C54355233 @default.
- W4253222912 hasConcept C552990157 @default.
- W4253222912 hasConcept C86803240 @default.
- W4253222912 hasConcept C91779695 @default.
- W4253222912 hasConcept C95444343 @default.
- W4253222912 hasConceptScore W4253222912C104317684 @default.
- W4253222912 hasConceptScore W4253222912C134018914 @default.
- W4253222912 hasConceptScore W4253222912C153911025 @default.
- W4253222912 hasConceptScore W4253222912C189165786 @default.
- W4253222912 hasConceptScore W4253222912C22744801 @default.
- W4253222912 hasConceptScore W4253222912C2780644872 @default.
- W4253222912 hasConceptScore W4253222912C38008103 @default.
- W4253222912 hasConceptScore W4253222912C54355233 @default.
- W4253222912 hasConceptScore W4253222912C552990157 @default.
- W4253222912 hasConceptScore W4253222912C86803240 @default.
- W4253222912 hasConceptScore W4253222912C91779695 @default.
- W4253222912 hasConceptScore W4253222912C95444343 @default.
- W4253222912 hasIssue "s1" @default.
- W4253222912 hasLocation W42532229121 @default.
- W4253222912 hasLocation W42532229122 @default.
- W4253222912 hasOpenAccess W4253222912 @default.
- W4253222912 hasPrimaryLocation W42532229121 @default.
- W4253222912 hasRelatedWork W1571771606 @default.
- W4253222912 hasRelatedWork W1968976175 @default.
- W4253222912 hasRelatedWork W2026612772 @default.
- W4253222912 hasRelatedWork W2050897266 @default.
- W4253222912 hasRelatedWork W2163703477 @default.
- W4253222912 hasRelatedWork W2171329180 @default.
- W4253222912 hasRelatedWork W2414030161 @default.