Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253247767> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4253247767 endingPage "858" @default.
- W4253247767 startingPage "858" @default.
- W4253247767 abstract "During a 2-year chronic inhalation study on methylene chloride (2000 or 0 ppm; 6 hr/day, 5 days/week), gas-uptake pharmacokinetic studies and tissue partition coefficient determinations were conducted on female B6C3F1, mice after 1 day, 1 month, 1 year, and 2 years of exposure. Using physiologically based pharmacokinetic (PBPK) modeling coupled with Monte Carlo simulation and bootstrap resampling for data analyses, a significant induction in the mixed function oxidase (MFO) rate constant (Vmaxc) was observed at the 1-day and 1-month exposure points when compared to concurrent control mice while decreases in glutathione S-transferase (GST) rate constant (Kfc) were observed in the 1-day and 1-month exposed mice. Within exposure groups, the apparent Vmaxc maintained significant increases in the 1-month and 2-year control groups. Although the same initial increase exists in the exposed group, the 2-year Vmaxc is significantly smaller than the 1-month group (p < 0.001). Within group differences in median Kfc values show a significant decrease in both 1-month and 2-year groups among control and exposed mice (p < 0.001). Although no changes in methylene chloride solubility as a result of prior exposure were observed in blood, muscle, liver, or lung, a marginal decrease in the fat:air partition coefficient was found in the exposed mice at p = 0.053. Age related solubility differences were found in muscle:air, liver:air, lung:air, and fat:air partition coefficients at p < 0.001, while the solubility of methylene chloride in blood was not affected by age (p = 0.461). As a result of this study, we conclude that age and prior exposure to methylene chloride can produce notable changes in disposition and metabolism and may represent important factors in the interpretation for toxicologic data and its application to risk assessment." @default.
- W4253247767 created "2022-05-12" @default.
- W4253247767 creator A5024659936 @default.
- W4253247767 creator A5026001980 @default.
- W4253247767 creator A5028642008 @default.
- W4253247767 creator A5036400318 @default.
- W4253247767 creator A5038393989 @default.
- W4253247767 creator A5059122338 @default.
- W4253247767 creator A5060338827 @default.
- W4253247767 creator A5062975181 @default.
- W4253247767 creator A5067027797 @default.
- W4253247767 creator A5078096708 @default.
- W4253247767 date "1996-08-01" @default.
- W4253247767 modified "2023-09-30" @default.
- W4253247767 title "PBPK Modeling/Monte Carlo Simulation of Methylene Chloride Kinetic Changes in Mice in Relation to Age and Acute, Subchronic, and Chronic Inhalation Exposure" @default.
- W4253247767 doi "https://doi.org/10.2307/3432940" @default.
- W4253247767 hasPublicationYear "1996" @default.
- W4253247767 type Work @default.
- W4253247767 citedByCount "0" @default.
- W4253247767 crossrefType "journal-article" @default.
- W4253247767 hasAuthorship W4253247767A5024659936 @default.
- W4253247767 hasAuthorship W4253247767A5026001980 @default.
- W4253247767 hasAuthorship W4253247767A5028642008 @default.
- W4253247767 hasAuthorship W4253247767A5036400318 @default.
- W4253247767 hasAuthorship W4253247767A5038393989 @default.
- W4253247767 hasAuthorship W4253247767A5059122338 @default.
- W4253247767 hasAuthorship W4253247767A5060338827 @default.
- W4253247767 hasAuthorship W4253247767A5062975181 @default.
- W4253247767 hasAuthorship W4253247767A5067027797 @default.
- W4253247767 hasAuthorship W4253247767A5078096708 @default.
- W4253247767 hasBestOaLocation W42532477671 @default.
- W4253247767 hasConcept C112705442 @default.
- W4253247767 hasConcept C126322002 @default.
- W4253247767 hasConcept C134018914 @default.
- W4253247767 hasConcept C178790620 @default.
- W4253247767 hasConcept C185592680 @default.
- W4253247767 hasConcept C185867374 @default.
- W4253247767 hasConcept C192552737 @default.
- W4253247767 hasConcept C195289149 @default.
- W4253247767 hasConcept C2776954882 @default.
- W4253247767 hasConcept C2779777708 @default.
- W4253247767 hasConcept C29730261 @default.
- W4253247767 hasConcept C33070731 @default.
- W4253247767 hasConcept C42219234 @default.
- W4253247767 hasConcept C43617362 @default.
- W4253247767 hasConcept C71924100 @default.
- W4253247767 hasConcept C86803240 @default.
- W4253247767 hasConcept C98274493 @default.
- W4253247767 hasConceptScore W4253247767C112705442 @default.
- W4253247767 hasConceptScore W4253247767C126322002 @default.
- W4253247767 hasConceptScore W4253247767C134018914 @default.
- W4253247767 hasConceptScore W4253247767C178790620 @default.
- W4253247767 hasConceptScore W4253247767C185592680 @default.
- W4253247767 hasConceptScore W4253247767C185867374 @default.
- W4253247767 hasConceptScore W4253247767C192552737 @default.
- W4253247767 hasConceptScore W4253247767C195289149 @default.
- W4253247767 hasConceptScore W4253247767C2776954882 @default.
- W4253247767 hasConceptScore W4253247767C2779777708 @default.
- W4253247767 hasConceptScore W4253247767C29730261 @default.
- W4253247767 hasConceptScore W4253247767C33070731 @default.
- W4253247767 hasConceptScore W4253247767C42219234 @default.
- W4253247767 hasConceptScore W4253247767C43617362 @default.
- W4253247767 hasConceptScore W4253247767C71924100 @default.
- W4253247767 hasConceptScore W4253247767C86803240 @default.
- W4253247767 hasConceptScore W4253247767C98274493 @default.
- W4253247767 hasIssue "8" @default.
- W4253247767 hasLocation W42532477671 @default.
- W4253247767 hasOpenAccess W4253247767 @default.
- W4253247767 hasPrimaryLocation W42532477671 @default.
- W4253247767 hasRelatedWork W1973535044 @default.
- W4253247767 hasRelatedWork W2020325106 @default.
- W4253247767 hasRelatedWork W2069069164 @default.
- W4253247767 hasRelatedWork W2078828471 @default.
- W4253247767 hasRelatedWork W2089346418 @default.
- W4253247767 hasRelatedWork W2098932414 @default.
- W4253247767 hasRelatedWork W2148104899 @default.
- W4253247767 hasRelatedWork W2398231413 @default.
- W4253247767 hasRelatedWork W289239311 @default.
- W4253247767 hasRelatedWork W4210823161 @default.
- W4253247767 hasVolume "104" @default.
- W4253247767 isParatext "false" @default.
- W4253247767 isRetracted "false" @default.
- W4253247767 workType "article" @default.