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- W4253272439 abstract "Abstract The development of nephrotic-range proteinuria after renal transplantation is an unfavourable prognostic factor for graft survival. In contrast to that in other nephropathies, the role of renin-angiotensin blockade in kidney transplantation is less well defined, and its anti-proteinuric effect is markedly reduced in the presence of segmental glomerulosclerosis. Here, we describe two patients who developed severe proteinuria after renal transplantation, despite effective blood pressure control with an ACE inhibitor. Histological changes were consistent with IgAnephropathy and focal segmental glomerulosclerosis. Both patients were treated with low-molecularweight heparin in addition to preexisting ACE inhibition. This regimen led to a significant and longlasting reduction of proteinuria. Our data suggest that low-molecular-weight heparin possesses strong renoprotective properties, thus confirming previous data from experimental nephropathies. This approach might represent a promising new strategy for treatment of proteinuria after kidney transplantation." @default.
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- W4253272439 date "2004-09-01" @default.
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- W4253272439 title "Treatment of proteinuria with low-molecularweight heparin after renal transplantation" @default.
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- W4253272439 doi "https://doi.org/10.1111/j.1432-2277.2004.tb00472.x" @default.
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