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- W4253282805 endingPage "re20" @default.
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- W4253282805 abstract "Interactions between Eph receptors and their ligands the ephrin proteins are critically important in many key developmental processes. Emerging evidence also supports a role for these molecules in postembryonic tissues, particularly in pathological processes, including tissue injury and tumor metastasis. We review the signaling mechanisms that allow the 14 Eph and nine ephrin proteins to deliver intracellular signals that regulate cell shape and movement. What emerges is that the initiation of these signals is critically dependent on which Eph and ephrin proteins are expressed, the level of their expression, and, in some cases, which splice variants are expressed. Diversity at the level of initial interaction and in the downstream signaling processes regulated by Eph-ephrin signaling provides a subtle, versatile system of regulation of intercellular adhesion, cell shape, and cell motility." @default.
- W4253282805 created "2022-05-12" @default.
- W4253282805 creator A5078740025 @default.
- W4253282805 creator A5090491025 @default.
- W4253282805 date "2001-12-11" @default.
- W4253282805 modified "2023-10-18" @default.
- W4253282805 title "Signals from Eph and Ephrin Proteins: A Developmental Tool Kit" @default.
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- W4253282805 doi "https://doi.org/10.1126/scisignal.1122001re20" @default.
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