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- W4253313400 abstract "Some essential hypertensive patients and genetic hypertensive rat strains have less than the normal levels of Mg 2+ tightly bound to the plasma membranes of their erythrocytes and other cells, i.e., the magnesium binding defect (MgBD). This binding defect appears to cause increased passive permeability of the membrane to Na + and thereby its increased intracellular concentration, particularly if the Na + -extrusion enzyme systems of the cell are also defective. The Na + -Ca 2+ exchange system in the cell membrane exports Na + and imports Ca 2+ , increasing the tone of the smooth muscle cell and thus producing hypertension (HTn). This HTn is Na + -sensitive. Evidence supporting this postulate was obtained by determining the intraerythrocyte total concentrations of Na + , Ca 2+ , K + , and Mg 2+ in two strains of spontaneously hypertensive rats (SHR and SS/Jr rats, having the MgBD together with the other requisites of the Na + -sensitive pathway) and their respective controls (WKY and SR/Jr rats, in which this complete pathway is absent). The Na + and Ca 2+ concentrations in the hypertensive rats were increased, and that of K + was decreased. The concentrations of these cations were very similar in the two hypertensive strains. The level of membrane tightly bound Ca 2+ in SHR erythrocyte membranes was significantly higher than those in the other three rat strains, which were not statistically different from each other. These results support previously reported evidence of the existence of a novel HTn-generating mechanism in the SHR rat, in which the intracellular Ca 2+ concentration is increased as the result of the enhanced diffusion of this ion into the cell and the accompanying deficiency of the Ca 2+ extrusion enzyme systems. This pathway is therefore Na + -insensitive, i.e., Ca 2+ -sensitive.Key words: essential hypertension, Na + -sensitive hypertension, Na + -insensitive hypertension, Ca 2+ -sensitive hypertension." @default.
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- W4253313400 date "2001-09-01" @default.
- W4253313400 modified "2023-09-24" @default.
- W4253313400 title "Coexisting independent sodium-sensitive and sodium-insensitive mechanisms of genetic hypertension in spontaneously hypertensive rats (SHR)" @default.
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- W4253313400 doi "https://doi.org/10.1139/y01-061" @default.
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