Matches in SemOpenAlex for { <https://semopenalex.org/work/W4253327795> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W4253327795 endingPage "338" @default.
- W4253327795 startingPage "329" @default.
- W4253327795 abstract "Levels of plasma amino acids, ammonia, glucagon and insulin and their 5-hr responses to a protein feeding were evaluated before and sequentially (3 mo and 1 yr) after distal splenorenal shunt in 10 patients with cirrhosis belonging to Child-Pugh's class A or B. An index of glucagon effectiveness (plasma glucose/glucagon) was also calculated. These parameters were related to liver test results, portal vein diameter and mental state, and they were compared with those found in seven patients undergoing sclerotherapy of esophageal varices with comparable liver function (control group). Liver test results and levels of plasma insulin did not change in either group. Shunt significantly increased levels of fasting tyrosine, methionine, ornithine, arginine, histidine, ammonia and glucagon with respect to the control group; it also significantly decreased levels of leucine, valine, glucagon effectiveness and portal vein diameter. The elevation of levels of tyrosine, ammonia and the sum of arginine and ornithine was correlated directly with the increase in glucagon and inversely with the decline in glucagon effectiveness. Tyrosine increase was also correlated with the reduction of portal vein diameter. One shunted patient showed mild hepatic encephalopathy. Protein feeding did not worsen the mental state of patients before and after the operation. Surgery significantly increased the 5-hr response to the meal of gluconeogenic amino acids; its rise was again correlated with the changes in glucagon plasma levels and effectiveness. Although the absorptive levels of plasma ammonia were significantly higher 1 yr after surgery, its 5-hr response barely rose. In cirrhotic patients with a relatively preserved liver function, distal splenorenal shunt progressively worsened the fasting plasma profile of nitrogen compounds and the response to protein ingestion of gluconeogenic amino acids. The decline of portal blood flow and glucagon effectiveness may be causal factors. Despite this, the “cerebral” tolerance to a moderate oral load of protein was not reduced by surgery. (Hepatology 1994;19:329–338)." @default.
- W4253327795 created "2022-05-12" @default.
- W4253327795 creator A5030619209 @default.
- W4253327795 date "1994-02-01" @default.
- W4253327795 modified "2023-10-16" @default.
- W4253327795 title "Early and late changes in fasting and absorptive plasma amino acids and ammonia after distal splenorenal shunt in cirrhosis" @default.
- W4253327795 doi "https://doi.org/10.1016/0270-9139(94)90009-4" @default.
- W4253327795 hasPublicationYear "1994" @default.
- W4253327795 type Work @default.
- W4253327795 citedByCount "0" @default.
- W4253327795 crossrefType "journal-article" @default.
- W4253327795 hasAuthorship W4253327795A5030619209 @default.
- W4253327795 hasBestOaLocation W42533277951 @default.
- W4253327795 hasConcept C126322002 @default.
- W4253327795 hasConcept C134018914 @default.
- W4253327795 hasConcept C185592680 @default.
- W4253327795 hasConcept C2777214474 @default.
- W4253327795 hasConcept C2777468819 @default.
- W4253327795 hasConcept C2777595160 @default.
- W4253327795 hasConcept C2778563252 @default.
- W4253327795 hasConcept C2778808290 @default.
- W4253327795 hasConcept C2779306644 @default.
- W4253327795 hasConcept C515207424 @default.
- W4253327795 hasConcept C55493867 @default.
- W4253327795 hasConcept C71924100 @default.
- W4253327795 hasConceptScore W4253327795C126322002 @default.
- W4253327795 hasConceptScore W4253327795C134018914 @default.
- W4253327795 hasConceptScore W4253327795C185592680 @default.
- W4253327795 hasConceptScore W4253327795C2777214474 @default.
- W4253327795 hasConceptScore W4253327795C2777468819 @default.
- W4253327795 hasConceptScore W4253327795C2777595160 @default.
- W4253327795 hasConceptScore W4253327795C2778563252 @default.
- W4253327795 hasConceptScore W4253327795C2778808290 @default.
- W4253327795 hasConceptScore W4253327795C2779306644 @default.
- W4253327795 hasConceptScore W4253327795C515207424 @default.
- W4253327795 hasConceptScore W4253327795C55493867 @default.
- W4253327795 hasConceptScore W4253327795C71924100 @default.
- W4253327795 hasIssue "2" @default.
- W4253327795 hasLocation W42533277951 @default.
- W4253327795 hasOpenAccess W4253327795 @default.
- W4253327795 hasPrimaryLocation W42533277951 @default.
- W4253327795 hasRelatedWork W1974106130 @default.
- W4253327795 hasRelatedWork W1981564790 @default.
- W4253327795 hasRelatedWork W1988703247 @default.
- W4253327795 hasRelatedWork W2020975625 @default.
- W4253327795 hasRelatedWork W2036160461 @default.
- W4253327795 hasRelatedWork W2084766474 @default.
- W4253327795 hasRelatedWork W2100873783 @default.
- W4253327795 hasRelatedWork W2103733301 @default.
- W4253327795 hasRelatedWork W2106152476 @default.
- W4253327795 hasRelatedWork W2144753412 @default.
- W4253327795 hasVolume "19" @default.
- W4253327795 isParatext "false" @default.
- W4253327795 isRetracted "false" @default.
- W4253327795 workType "article" @default.