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- W4253347640 endingPage "301" @default.
- W4253347640 startingPage "287" @default.
- W4253347640 abstract "This chapter describes the tissue distribution, function, and structure of MYC . The v- myc oncogene was first detected in avian myelocytomatosis virus MC29. Myc has also been transduced by the acutely transforming avian retroviruses CMII, OK10, MH2, and FH3. MYC is a member of the helix-loop-helix/leucine zipper super family. It is detectable in the cytoplasm of colorectal tumor cells and serum-starved fibroblasts. It is expressed during proliferation in a wide variety of adult tissues and at all stages of embryonal development. MYCN and MYCL expressions are generally restricted to embryonic brain, kidney, and lung, suggesting their possible involvement in differentiation. MYC , MYCN , and MYCL are helix-loop-helix/leucine zipper (HLH/LZ) proteins that form heterodimers with MAX that have a high affinity for the core consensus sequence CACGTG and lower affinity for various noncanonical DNA sequences. The members of the MYC family possess common functional elements and trans -activation incompetent mutants of one member can act in trans to suppress dominantly the cotransformation activities of all three MYC proteins. It is found that in human colon cancer cells, thymidylate synthase binds to the 3’ coding region of MYC mRNA and inhibits MYC translational efficiency." @default.
- W4253347640 created "2022-05-12" @default.
- W4253347640 creator A5039947845 @default.
- W4253347640 date "1997-01-01" @default.
- W4253347640 modified "2023-09-25" @default.
- W4253347640 title "MYC" @default.
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